|
gptkbp:instanceOf
|
signaling molecule
|
|
gptkbp:activatedBy
|
gptkb:insulin
cytokines
growth factors
|
|
gptkbp:alsoKnownAs
|
gptkb:PI3K/AKT_pathway
|
|
gptkbp:component
|
gptkb:4EBP1
gptkb:PIP3
gptkb:S6K
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
gptkb:GSK3
gptkb:MDM2
gptkb:PDK1
gptkb:TSC1/TSC2_complex
gptkb:mTOR
gptkb:p27kip1
|
|
gptkbp:downstreamOf
|
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:diabetes
cardiovascular diseases
|
|
gptkbp:firstDescribed
|
1990s
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3K-AKT pathway
|
|
gptkbp:inhibitedBy
|
gptkb:PTEN
AKT inhibitors
PI3K inhibitors
|
|
gptkbp:involves
|
gptkb:phosphoinositide_3-kinase_(PI3K)
gptkb:AKT_(protein_kinase_B)
|
|
gptkbp:regulates
|
cell proliferation
cell survival
metabolism
angiogenesis
cell growth
cell migration
|
|
gptkbp:studiedIn
|
cell biology
oncology
metabolic diseases
|
|
gptkbp:target
|
anticancer drugs
targeted therapies
|
|
gptkbp:bfsParent
|
gptkb:EGFR_signaling_pathway
gptkb:NRAS_protein
|
|
gptkbp:bfsLayer
|
6
|