|
gptkbp:instanceOf
|
gptkb:signaling_molecule
|
|
gptkbp:activatedBy
|
cytokines
growth factors
|
|
gptkbp:alsoKnownAs
|
gptkb:JAK-STAT_pathway
|
|
gptkbp:contains
|
gptkb:STAT1
gptkb:STAT2
gptkb:STAT4
gptkb:STAT5A
gptkb:STAT5B
gptkb:STAT6
gptkb:STAT3
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
autoimmune diseases
inflammatory diseases
|
|
gptkbp:function
|
regulates gene expression
transmits signals from cell surface to nucleus
|
|
gptkbp:hasRole
|
gptkb:immune_response
apoptosis
cell differentiation
cell growth
|
|
gptkbp:involves
|
gptkb:Signal_Transducers_and_Activators_of_Transcription_(STATs)
Janus kinases (JAKs)
|
|
gptkbp:mechanismOfAction
|
JAKs phosphorylate STATs
STAT dimers translocate to nucleus
STATs bind DNA and regulate transcription
ligand binds receptor
phosphorylated STATs dimerize
|
|
gptkbp:studiedIn
|
immunology
oncology
hematology
|
|
gptkbp:target
|
therapeutic inhibitors
|
|
gptkbp:bfsParent
|
gptkb:EGFR_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
STAT pathway
|