Statements (36)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
signaling molecule
|
| gptkbp:activatedBy |
cytokines
growth factors |
| gptkbp:alsoKnownAs |
gptkb:JAK-STAT_pathway
|
| gptkbp:contains |
gptkb:STAT1
gptkb:STAT2 gptkb:STAT4 gptkb:STAT5A gptkb:STAT5B gptkb:STAT6 gptkb:STAT3 |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
autoimmune diseases inflammatory diseases |
| gptkbp:function |
regulates gene expression
transmits signals from cell surface to nucleus |
| gptkbp:hasRole |
apoptosis
cell differentiation cell growth immune response |
| https://www.w3.org/2000/01/rdf-schema#label |
STAT pathway
|
| gptkbp:involves |
gptkb:Signal_Transducers_and_Activators_of_Transcription_(STATs)
Janus kinases (JAKs) |
| gptkbp:mechanismOfAction |
JAKs phosphorylate STATs
STAT dimers translocate to nucleus STATs bind DNA and regulate transcription ligand binds receptor phosphorylated STATs dimerize |
| gptkbp:studiedIn |
immunology
oncology hematology |
| gptkbp:target |
therapeutic inhibitors
|
| gptkbp:bfsParent |
gptkb:c-Met
gptkb:EGFR_signaling_pathway |
| gptkbp:bfsLayer |
6
|