Statements (38)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
cytokines
growth factors Janus kinases (JAKs) |
| gptkbp:binds |
specific DNA sequences
|
| gptkbp:discoveredBy |
gptkb:James_E._Darnell
|
| gptkbp:domain |
SH2 domain
DNA-binding domain transactivation domain |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
autoimmune diseases inflammatory diseases |
| gptkbp:firstDescribed |
1994
|
| gptkbp:form |
hetero-dimers
homo-dimers |
| gptkbp:fullName |
gptkb:Signal_Transducer_and_Activator_of_Transcription_proteins
|
| gptkbp:function |
signal transduction
transcription factor |
| https://www.w3.org/2000/01/rdf-schema#label |
STATs
|
| gptkbp:involvedIn |
apoptosis
differentiation cell growth immune response |
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:member |
gptkb:STAT1
gptkb:STAT2 gptkb:STAT4 gptkb:STAT5A gptkb:STAT5B gptkb:STAT6 gptkb:STAT3 |
| gptkbp:phosphorylates |
gptkb:JAKs
|
| gptkbp:species |
gptkb:human
gptkb:mouse other vertebrates |
| gptkbp:bfsParent |
gptkb:EGFR_signaling_pathway
|
| gptkbp:bfsLayer |
6
|