Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
signaling molecule
|
| gptkbp:activatedBy |
gptkb:receptor_tyrosine_kinases
growth factors |
| gptkbp:alsoKnownAs |
gptkb:MAPK/ERK_pathway
|
| gptkbp:componentOrder |
RAS → RAF → MEK → ERK
|
| gptkbp:downstreamOf |
gptkb:EGFR
gptkb:FGFR |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
developmental disorders |
| gptkbp:firstDescribed |
1990s
|
| https://www.w3.org/2000/01/rdf-schema#label |
RAS-RAF-MEK-ERK pathway
|
| gptkbp:inhibitedBy |
gptkb:MEK_inhibitors
gptkb:RAF_inhibitors ERK inhibitors |
| gptkbp:involvesProtein |
gptkb:RAS
gptkb:RAF gptkb:ERK gptkb:MEK |
| gptkbp:regulates |
cell differentiation
cell proliferation cell survival gene expression |
| gptkbp:studiedIn |
gptkb:pharmacy
cell biology oncology |
| gptkbp:type |
gptkb:MAPK_pathway
|
| gptkbp:bfsParent |
gptkb:EGFR_signaling_pathway
|
| gptkbp:bfsLayer |
6
|