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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
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gptkb:ERBB1
gptkb:HER1
|
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gptkbp:associatedWith
|
gptkb:non-small_cell_lung_cancer
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
head and neck cancer
|
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gptkbp:discoveredBy
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gptkb:Stanley_Cohen
|
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gptkbp:discoveredIn
|
1980
|
|
gptkbp:domain
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000146648
|
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gptkbp:family
|
gptkb:ErbB_family
|
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gptkbp:fullName
|
gptkb:Epidermal_Growth_Factor_Receptor
|
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gptkbp:function
|
gptkb:receptor_tyrosine_kinase
cell differentiation regulation
cell proliferation regulation
cell survival regulation
|
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gptkbp:gene
|
gptkb:EGFR
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EGFR protein
|
|
gptkbp:ligand
|
gptkb:amphiregulin
gptkb:betacellulin
gptkb:epidermal_growth_factor_(EGF)
gptkb:epiregulin
gptkb:transforming_growth_factor_alpha_(TGF-α)
gptkb:heparin-binding_EGF-like_growth_factor
epigen
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p11.2
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~170 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:L858R
gptkb:T790M
exon 19 deletion
exon 20 insertion
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:ERBB3
gptkb:ERBB2
gptkb:ERBB4
|
|
gptkbp:pathway
|
gptkb:PLCγ_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
|
|
gptkbp:PDB
|
1M17
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
ubiquitination
|
|
gptkbp:structure
|
single-pass type I membrane protein
|
|
gptkbp:target
|
gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
gptkb:necitumumab
gptkb:panitumumab
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|
gptkbp:UniProtID
|
gptkb:P00533
|
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gptkbp:bfsParent
|
gptkb:NP_005334.1
|
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gptkbp:bfsLayer
|
6
|