|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:HER4
NRG1 receptor
proto-oncogene-like protein c-erbB-4
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
amyotrophic lateral sclerosis
schizophrenia
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
signal transduction
apoptotic process
protein tyrosine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
Yarden Y et al.
|
|
gptkbp:EC_number
|
2.7.10.1
|
|
gptkbp:encodes
|
Receptor tyrosine-protein kinase erbB-4
|
|
gptkbp:Entrez_Gene_ID
|
2066
ENSG00000178568
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
brain
heart
breast tissue
|
|
gptkbp:function
|
apoptosis
differentiation
cell signaling
cell growth regulation
|
|
gptkbp:gene
|
gptkb:ERBB4
|
|
gptkbp:hasRefSeqID
|
NM_005235
|
|
gptkbp:HGNC_ID
|
3431
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERBB4
|
|
gptkbp:interactsWith
|
gptkb:EGFR
gptkb:ERBB3
gptkb:ERBB2
|
|
gptkbp:ligand
|
gptkb:betacellulin
gptkb:epiregulin
gptkb:heparin-binding_EGF-like_growth_factor
neuregulins
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
2q34
|
|
gptkbp:memberOf
|
gptkb:receptor_tyrosine_kinases
gptkb:ErbB_family
|
|
gptkbp:OMIM
|
600543
|
|
gptkbp:orthologInMouse
|
Erbb4
|
|
gptkbp:PDB
|
2R4B
3BCE
3U7U
|
|
gptkbp:UniProtID
|
Q15303
|
|
gptkbp:bfsParent
|
gptkb:P42336
|
|
gptkbp:bfsLayer
|
6
|