Epidermal Growth Factor Receptor
GPTKB entity
Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:clinical_trial |
poor prognosis in cancers
predictor of response to therapy |
| gptkbp:communication_system |
gptkb:survival
gptkb:migration differentiation angiogenesis proliferation |
| gptkbp:diseases |
gptkb:Oncology
head and neck cancer |
| gptkbp:function |
cell signaling
|
| gptkbp:genetic_studies |
common in lung cancer
|
| https://www.w3.org/2000/01/rdf-schema#label |
Epidermal Growth Factor Receptor
|
| gptkbp:initiated_by |
gptkb:osimertinib
afatinib erlotinib gefitinib cetuximab dimerization EGFR inhibitors |
| gptkbp:interacts_with |
with ligands
|
| gptkbp:is_expressed_in |
overexpressed in many tumors
|
| gptkbp:location |
cell membrane
|
| gptkbp:pathway |
MAPK pathway
PI3 K/ AKT pathway |
| gptkbp:promoter |
gptkb:EGFR
|
| gptkbp:related_products |
epidermal growth factor
|
| gptkbp:research |
biomarker for cancer
potential for personalized medicine target for drug development effects on apoptosis impact on immune response influence on drug metabolism influence on tumor microenvironment involvement in cell cycle regulation potential for combination therapies role in resistance mechanisms association with inflammatory responses association with other receptors association with patient survival impact on quality of life in patients impact on treatment outcomes influence on tumor heterogeneity involvement in resistance to therapy involvement in signaling networks potential for novel therapeutic strategies role in cancer stem cells role in epithelial-mesenchymal transition role in metastasis |
| gptkbp:role |
tumor growth
|
| gptkbp:targets |
target for cancer therapy
|
| gptkbp:type |
tyrosine kinase receptor
|
| gptkbp:bfsParent |
gptkb:EGFR
|
| gptkbp:bfsLayer |
5
|