Epidermal Growth Factor Receptor

URI: https://gptkb.org/entity/Epidermal_Growth_Factor_Receptor
GPTKB entity
Statements (55)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:abbreviation gptkb:EGFR
gptkbp:alternativeName gptkb:ERBB1
gptkb:HER1
gptkbp:associatedWith gptkb:non-small_cell_lung_cancer
gptkb:glioblastoma
colorectal cancer
head and neck cancer
gptkbp:biologicalProcess receptor tyrosine kinase activity
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:discoveredBy gptkb:Stanley_Cohen
gptkbp:discoveredIn 1980
gptkbp:Entrez_Gene_ID gptkb:ENSG00000146648
gptkbp:expressedIn gptkb:skin
gastrointestinal tract
epithelial tissues
lung tissue
gptkbp:family gptkb:ErbB_family
gptkbp:form homodimer
heterodimer with other ErbB family members
gptkbp:function cell signaling
regulation of cell differentiation
regulation of cell proliferation
regulation of cell growth
gptkbp:gene gptkb:EGFR_gene
gptkbp:HGNC_ID 3236
https://www.w3.org/2000/01/rdf-schema#label Epidermal Growth Factor Receptor
gptkbp:ligand gptkb:epidermal_growth_factor
gptkb:transforming_growth_factor_alpha
gptkbp:locatedOnChromosome gptkb:chromosome_7
gptkbp:mutationAssociatedWith gptkb:L858R
gptkb:T790M
exon 19 deletion
gptkbp:OMIM 131550
gptkbp:orthologInMouse Egfr
gptkbp:pathway gptkb:PLCĪ³_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
gptkbp:phosphorylates tyrosine residues
gptkbp:structure transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
gptkbp:targetOfDrug gptkb:afatinib
gptkb:cetuximab
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
gptkbp:UniProtID gptkb:P00533
gptkbp:bfsParent gptkb:EGFR_protein
gptkb:Epidermal_Growth_Factor_Receptor_signaling_pathway
gptkb:EGDR
gptkb:HER1
gptkbp:bfsLayer 7