|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
HER2
neu
|
|
gptkbp:associatedWith
|
gptkb:cancer
gastric cancer
|
|
gptkbp:discoveredBy
|
gptkb:Axel_Ullrich
|
|
gptkbp:domain
|
extracellular domain
transmembrane domain
tyrosine kinase domain
cytoplasmic domain
|
|
gptkbp:encodes
|
Receptor tyrosine-protein kinase erbB-2
|
|
gptkbp:Entrez_Gene_ID
|
2064
ENSG00000141736
|
|
gptkbp:expressedIn
|
epithelial cells
|
|
gptkbp:formsHeterodimerWith
|
gptkb:EGFR
gptkb:ERBB3
gptkb:ERBB4
|
|
gptkbp:function
|
signal transduction
receptor tyrosine kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
3430
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERBB2
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
cell survival
cell growth
|
|
gptkbp:length
|
1255 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
gptkb:17q12
|
|
gptkbp:memberOf
|
gptkb:EGFR_family
|
|
gptkbp:molecularWeight
|
137 kDa
|
|
gptkbp:OMIM
|
164870
|
|
gptkbp:orthologInMouse
|
Erbb2
|
|
gptkbp:overexpressedIn
|
tumorigenesis
|
|
gptkbp:pathway
|
gptkb:Focal_adhesion
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
gptkb:ErbB_signaling_pathway
Cell cycle regulation
Adherens junction
Apoptosis regulation
|
|
gptkbp:PDB
|
gptkb:2A91
gptkb:3RCD
3PP0
3BE1
3WSQ
|
|
gptkbp:phosphorylates
|
gptkb:SRC
gptkb:ABL1
|
|
gptkbp:regulates
|
miR-125a
miR-125b
miR-205
|
|
gptkbp:targetOfDrug
|
gptkb:ado-trastuzumab_emtansine
gptkb:pertuzumab
gptkb:trastuzumab
gptkb:tucatinib
gptkb:lapatinib
gptkb:neratinib
|
|
gptkbp:UniProtID
|
gptkb:P04626
|
|
gptkbp:bfsParent
|
gptkb:P42336
gptkb:chromosome_17
|
|
gptkbp:bfsLayer
|
6
|