transforming growth factor alpha (TGF-α)

URI: https://gptkb.org/entity/transforming_growth_factor_alpha_(TGF-α)
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:TGF-alpha
gptkbp:associatedWith gptkb:cancer
gptkbp:binds gptkb:epidermal_growth_factor_receptor_(EGFR)
gptkbp:category growth factor
cytokine
gptkbp:discoveredBy gptkb:Stanley_Cohen
gptkbp:encodedBy gptkb:TGFA_gene
gptkbp:firstDescribed 1985
gptkbp:foundIn humans
mice
gptkbp:function cell differentiation
cell proliferation
wound healing
https://www.w3.org/2000/01/rdf-schema#label transforming growth factor alpha (TGF-α)
gptkbp:involvedIn tissue regeneration
embryogenesis
gptkbp:locatedOnChromosome gptkb:human_chromosome_2p13
gptkbp:memberOf gptkb:epidermal_growth_factor_family
gptkbp:molecularWeight 5.6 kDa (mature form)
gptkbp:overexpressedIn tumorigenesis
gptkbp:postTranslationalModification glycosylation
disulfide bond formation
gptkbp:predecessor membrane-anchored precursor protein
gptkbp:promotion epithelial cell growth
fibroblast growth
gptkbp:relatedTo gptkb:epidermal_growth_factor_(EGF)
gptkbp:releaseYear proteolytic cleavage
gptkbp:structure single polypeptide chain
gptkbp:UniProtID gptkb:P01135
gptkbp:bfsParent gptkb:NP_005334.1
gptkbp:bfsLayer 6