heparin-binding EGF-like growth factor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:HB-EGF
gptkbp:alternativeSplicing	yes
gptkbp:associatedWith	gptkb:cancer atherosclerosis cardiac hypertrophy
gptkbp:binds	gptkb:heparin EGF receptor
gptkbp:component	gptkb:plasma_membrane extracellular region
gptkbp:discoveredBy	gptkb:Higashiyama_et_al.
gptkbp:encodedBy	gptkb:HBEGF_gene
gptkbp:Entrez_Gene_ID	1839
gptkbp:expressedIn	gptkb:cancer gptkb:kidney gptkb:placenta heart macrophages smooth muscle cells
gptkbp:firstDescribed	1991
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	growth factor activity chemotactic activity mitogenic activity
gptkbp:GOProcess	cell proliferation cell migration
gptkbp:involvedIn	cell proliferation wound healing angiogenesis tissue regeneration
gptkbp:locatedOnChromosome	5q31-q32
gptkbp:location	gptkb:cell_membrane extracellular space
gptkbp:memberOf	gptkb:EGF_family
gptkbp:molecularWeight	22 kDa (precursor)
gptkbp:OMIM	126150
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:PDB	1BQC
gptkbp:postTranslationalModification	glycosylation proteolytic cleavage
gptkbp:recipient	gptkb:EGFR gptkb:ERBB4
gptkbp:RefSeq	NP_001915.2
gptkbp:UniProtID	Q99075
gptkbp:bfsParent	gptkb:EGFR_protein gptkb:P42338
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	heparin-binding EGF-like growth factor