heparin-binding EGF-like growth factor

URI: https://gptkb.org/entity/heparin-binding_EGF-like_growth_factor
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:HB-EGF
gptkbp:alternativeSplicing yes
gptkbp:associatedWith gptkb:cancer
atherosclerosis
cardiac hypertrophy
gptkbp:binds gptkb:heparin
EGF receptor
gptkbp:component gptkb:plasma_membrane
extracellular region
gptkbp:discoveredBy gptkb:Higashiyama_et_al.
gptkbp:encodedBy gptkb:HBEGF_gene
gptkbp:Entrez_Gene_ID 1839
gptkbp:expressedIn gptkb:cancer
gptkb:kidney
gptkb:placenta
heart
macrophages
smooth muscle cells
gptkbp:firstDescribed 1991
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function growth factor activity
chemotactic activity
mitogenic activity
gptkbp:GOProcess cell proliferation
cell migration
https://www.w3.org/2000/01/rdf-schema#label heparin-binding EGF-like growth factor
gptkbp:involvedIn cell proliferation
wound healing
angiogenesis
tissue regeneration
gptkbp:locatedOnChromosome 5q31-q32
gptkbp:location gptkb:cell_membrane
extracellular space
gptkbp:memberOf gptkb:EGF_family
gptkbp:molecularWeight 22 kDa (precursor)
gptkbp:OMIM 126150
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 1BQC
gptkbp:postTranslationalModification glycosylation
proteolytic cleavage
gptkbp:recipient gptkb:EGFR
gptkb:ERBB4
gptkbp:RefSeq NP_001915.2
gptkbp:UniProtID Q99075
gptkbp:bfsParent gptkb:P42338
gptkbp:bfsLayer 6