|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
neuregulins
|
|
gptkbp:alsoKnownAs
|
gptkb:ErbB-3
gptkb:HER3
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:discoveredBy
|
Yarden Y et al.
|
|
gptkbp:encodes
|
gptkb:Receptor_tyrosine-protein_kinase_erbB-3
|
|
gptkbp:Entrez_Gene_ID
|
2065
ENSG00000065361
|
|
gptkbp:expressedIn
|
breast tissue
epithelial tissues
lung tissue
|
|
gptkbp:extracellularDomain
|
present
|
|
gptkbp:firstDescribed
|
1989
|
|
gptkbp:formsHeterodimerWith
|
gptkb:ERBB2
|
|
gptkbp:function
|
cell signaling
receptor tyrosine kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasNo
|
intrinsic kinase activity
|
|
gptkbp:hasParalog
|
gptkb:EGFR
gptkb:ERBB2
gptkb:ERBB4
|
|
gptkbp:HGNC_ID
|
3431
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERBB3
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:ERBB2
|
|
gptkbp:intracellularDomain
|
present
|
|
gptkbp:involvedIn
|
cell survival
differentiation
signal transduction
cell growth
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12q13.2
|
|
gptkbp:memberOf
|
gptkb:EGFR_family
|
|
gptkbp:mutationAssociatedWith
|
cancer progression
gain-of-function
loss-of-function
|
|
gptkbp:OMIM
|
190151
|
|
gptkbp:orthologInMouse
|
gptkb:Erbb3
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:target
|
therapeutic antibodies
cancer drugs
|
|
gptkbp:transmembraneDomains
|
present
|
|
gptkbp:UniProtID
|
P21860
|
|
gptkbp:bfsParent
|
gptkb:P42336
gptkb:chromosome_12
|
|
gptkbp:bfsLayer
|
6
|