|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
phosphorylation
|
|
gptkbp:associatedWith
|
gptkb:cancer
developmental disorders
fibrosis
|
|
gptkbp:binds
|
gptkb:gene
transcription factors
|
|
gptkbp:Co-SMADs_include
|
gptkb:SMAD4
|
|
gptkbp:discoveredBy
|
gptkb:Joan_Massagué
|
|
gptkbp:domain
|
MH1 domain
MH2 domain
|
|
gptkbp:encodedBy
|
gptkb:SMAD_genes
|
|
gptkbp:firstDescribed
|
1996
|
|
gptkbp:formsComplexWith
|
other SMAD proteins
|
|
gptkbp:foundIn
|
animals
|
|
gptkbp:function
|
signal transduction
transcription regulation
|
|
gptkbp:gene
|
gptkb:SMAD
|
|
gptkbp:I-SMADs_include
|
gptkb:SMAD6
gptkb:SMAD7
|
|
gptkbp:inhibitedBy
|
gptkb:SMAD6
gptkb:SMAD7
|
|
gptkbp:involvedIn
|
gptkb:BMP_signaling_pathway
gptkb:TGF-beta_signaling_pathway
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:member
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:SMAD1
gptkb:SMAD5
gptkb:SMAD6
gptkb:SMAD7
gptkb:SMAD8
gptkb:SMAD9
gptkb:SMAD4
|
|
gptkbp:namedAfter
|
Mad gene (Drosophila)
Sma gene (C. elegans)
|
|
gptkbp:orthologIn
|
Mad (Drosophila)
Sma (C. elegans)
|
|
gptkbp:R-SMADs_include
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:SMAD1
gptkb:SMAD5
gptkb:SMAD8
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:subclassOf
|
gptkb:Co-SMADs
gptkb:I-SMADs
gptkb:R-SMADs
|
|
gptkbp:bfsParent
|
gptkb:BMP_signaling_pathway
gptkb:CDKN1A
gptkb:TGF-beta_receptor_family
gptkb:TGF-beta_signaling_pathway
gptkb:CDKN2B
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SMAD proteins
|