|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
dephosphorylation
|
|
gptkbp:binds
|
gptkb:gene
gptkb:forkhead_response_element
|
|
gptkbp:decommissioned
|
phosphorylation
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
various tissues
adipose tissue
immune cells
|
|
gptkbp:foundIn
|
animals
humans
|
|
gptkbp:function
|
transcription factors
|
|
gptkbp:gene
|
gptkb:FOXO
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FOXO proteins
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:diabetes
aging
neurodegenerative diseases
|
|
gptkbp:locatedOn
|
gptkb:chromosome_13_(FOXO1)
gptkb:chromosome_1_(FOXO6)
gptkb:chromosome_6_(FOXO3)
gptkb:chromosome_X_(FOXO4)
|
|
gptkbp:member
|
gptkb:FOXO1
gptkb:FOXO3
gptkb:FOXO4
gptkb:FOXO6
|
|
gptkbp:modulatedBy
|
gptkb:14-3-3_proteins
growth factors
methylation
insulin signaling
sirtuins
stress signals
ubiquitination
acetylation
nutrient availability
|
|
gptkbp:orthologIn
|
gptkb:DAF-16_(C._elegans)
|
|
gptkbp:phosphorylates
|
gptkb:Akt_kinase
|
|
gptkbp:regulates
|
apoptosis
longevity
DNA repair
metabolism
cell cycle
stem cell maintenance
autophagy
oxidative stress response
|
|
gptkbp:structure
|
forkhead DNA-binding domain
|
|
gptkbp:subclassOf
|
forkhead box proteins
|
|
gptkbp:bfsParent
|
gptkb:FOXO_transcription_factors
|
|
gptkbp:bfsLayer
|
6
|