ubiquitin-proteasome pathway

URI: https://gptkb.org/entity/ubiquitin-proteasome_pathway
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf biological pathway
gptkbp:alsoKnownAs ubiquitin-proteasome system
gptkbp:discoveredBy gptkb:Aaron_Ciechanover
gptkb:Avram_Hershko
gptkb:Irwin_Rose
gptkbp:discoveryAwarded gptkb:Nobel_Prize_in_Chemistry_2004
gptkbp:dysregulationAssociatedWith gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:cancer
neurodegenerative diseases
https://www.w3.org/2000/01/rdf-schema#label ubiquitin-proteasome pathway
gptkbp:involvesComplex gptkb:proteasome
gptkbp:involvesEnzyme gptkb:E1_ubiquitin-activating_enzyme
gptkb:E2_ubiquitin-conjugating_enzyme
E3 ubiquitin ligase
deubiquitinating enzyme
gptkbp:involvesModification ubiquitination
deubiquitination
gptkbp:involvesMolecule ubiquitin
gptkbp:involvesStructure gptkb:19S_regulatory_particle
gptkb:26S_proteasome
gptkb:20S_core_particle
gptkbp:occurredIn eukaryotic cells
gptkbp:processor protein degradation
protein unfolding
proteolysis
protein translocation
peptide cleavage
polyubiquitination
substrate recognition
ubiquitin recycling
gptkbp:regulates apoptosis
DNA repair
immune response
cell cycle
protein turnover
gptkbp:requires protein quality control
cellular homeostasis
antigen processing
regulation of transcription factors
removal of misfolded proteins
gptkbp:target gptkb:bortezomib
proteasome inhibitors
gptkbp:bfsParent gptkb:cyclin_A
gptkb:Myc
gptkb:p21
gptkb:c-Myc
gptkbp:bfsLayer 6