|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CDKN1A
gptkb:cyclin-dependent_kinase_inhibitor_1
gptkb:CIP1
gptkb:WAF1
|
|
gptkbp:category
|
gptkb:tumor_suppressor
CDK inhibitor
cell cycle inhibitor
|
|
gptkbp:discoveredBy
|
Xiong et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:CDKN1A_gene
|
|
gptkbp:Entrez_Gene_ID
|
1026
|
|
gptkbp:function
|
cell cycle regulation
inhibits cyclin-dependent kinases
|
|
gptkbp:inducedBy
|
gptkb:p53_protein
|
|
gptkbp:inhibitedBy
|
CDK2-cyclin E complex
CDK4-cyclin D complex
|
|
gptkbp:interactsWith
|
gptkb:CDK2
gptkb:CDK4
gptkb:PCNA
|
|
gptkbp:length
|
164 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.2
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1AXC
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
G1 phase of cell cycle
S phase of cell cycle
post-translational regulation
transcriptional regulation by p53
|
|
gptkbp:role
|
apoptosis
cell differentiation
cellular senescence
DNA damage response
tumor suppression
|
|
gptkbp:significance
|
gptkb:cancer
gptkb:cellular_stress_response
aging
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
gptkb:P38936
|
|
gptkbp:bfsParent
|
gptkb:CDKN1A
gptkb:v-Ha-ras
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p21 protein
|