Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cell cycle regulator |
| gptkbp:activatedBy |
mitogenic signals
|
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:binds |
gptkb:CDK4
gptkb:CDK6 |
| gptkbp:degradedBy |
gptkb:ubiquitin-proteasome_pathway
|
| gptkbp:encodedBy |
gptkb:CCND3
gptkb:CCND1 gptkb:CCND2 |
| gptkbp:family |
cyclin family
|
| gptkbp:foundIn |
eukaryotes
|
| https://www.w3.org/2000/01/rdf-schema#label |
cyclin D
|
| gptkbp:inhibitedBy |
CDK inhibitors
|
| gptkbp:molecularWeight |
~36 kDa
|
| gptkbp:orthologIn |
gptkb:mouse
gptkb:zebrafish gptkb:yeast |
| gptkbp:overexpressedIn |
gptkb:cancer
|
| gptkbp:phosphorylates |
gptkb:retinoblastoma_protein
Thr286 |
| gptkbp:regulates |
gptkb:G1/S_transition
cell cycle |
| gptkbp:role |
cell proliferation
cellular senescence apoptosis regulation tumorigenesis |
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:bfsParent |
gptkb:p21
gptkb:G1 |
| gptkbp:bfsLayer |
6
|