Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:cyclin-dependent_kinases
|
| gptkbp:associated_with |
gptkb:healthcare_organization
|
| gptkbp:challenges |
leads to uncontrolled cell proliferation
|
| gptkbp:clinical_trial |
ubiquitination
biomarker for cancer prognosis mediated by proteasome |
| gptkbp:established |
p16 IN K4a
p21 CI P1 p27 KI P1 |
| gptkbp:family |
cyclins
|
| gptkbp:form |
gptkb:cyclin_D1
cyclin D2 cyclin D3 |
| gptkbp:function |
regulates cell cycle progression
|
| gptkbp:genetic_diversity |
associated with various cancers
|
| https://www.w3.org/2000/01/rdf-schema#label |
cyclin D
|
| gptkbp:intelligence |
cyclin D-CD K4 complex
cyclin D-CD K6 complex |
| gptkbp:interacts_with |
CD K6
CD K4 with chromatin remodeling complexes with transcriptional co-activators |
| gptkbp:is_involved_in |
gptkb:embryonic_development
DNA damage response apoptosis regulation immune response inflammation wound healing cellular senescence tumorigenesis cellular differentiation tissue regeneration neurogenesis angiogenesis metastasis stem cell maintenance metabolic regulation G1 phase of cell cycle |
| gptkbp:is_represented_in |
regulated by growth factors
regulated by oncogenes regulated by tumor suppressors increased in breast cancer increased in colorectal cancer increased in lung cancer increased in many tumors increased in melanoma increased in prostate cancer |
| gptkbp:location |
gptkb:physicist
cytoplasm |
| gptkbp:metabolism |
activates CDK activity
|
| gptkbp:produced_by |
gene CCN D1
|
| gptkbp:regulatory_compliance |
via transcription factors
|
| gptkbp:research |
target for cancer therapy
|
| gptkbp:role |
cellular response to growth signals
cell cycle checkpoint regulation promotes transition from G1 to S phase |
| gptkbp:targets |
gptkb:retinoblastoma_protein_(Rb)
inhibitors of CD K4/6 |