|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abnormalActivityAssociatedWith
|
gptkb:cancer
autoimmune diseases
inflammatory diseases
|
|
gptkbp:activatedBy
|
cytokines
growth factors
tyrosine phosphorylation
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:database
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:HGNC
gptkb:UniProt
|
|
gptkbp:discoveredBy
|
gptkb:James_E._Darnell
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:form
|
hetero-dimers
homo-dimers
|
|
gptkbp:fullName
|
gptkb:Signal_Transducer_and_Activator_of_Transcription_proteins
|
|
gptkbp:function
|
gptkb:transcription_factor
signal transduction
|
|
gptkbp:involvedIn
|
gptkb:JAK-STAT_signaling_pathway
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:member
|
gptkb:STAT1
gptkb:STAT2
gptkb:STAT4
gptkb:STAT5A
gptkb:STAT5B
gptkb:STAT6
gptkb:STAT3
|
|
gptkbp:pathway
|
Erythropoietin signaling
Growth hormone signaling
IL-6 signaling
Interferon signaling
|
|
gptkbp:phosphorylates
|
tyrosine residue
|
|
gptkbp:proteinFamily
|
gptkb:STAT_gene_family
|
|
gptkbp:regulates
|
gptkb:immune_response
apoptosis
differentiation
cell growth
|
|
gptkbp:relatedTo
|
gptkb:JAK_kinases
cytokine receptors
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
SH2 domain
DNA-binding domain
transactivation domain
|
|
gptkbp:transcriptionalRegulation
|
cytokine-responsive genes
|
|
gptkbp:translocatesTo
|
gptkb:nucleus
|
|
gptkbp:bfsParent
|
gptkb:JAK-STAT_signaling_pathway
gptkb:JAK2
gptkb:CDKN1A
gptkb:JAK-STAT_pathway_activation
gptkb:p21
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
STAT proteins
|