multidrug resistance-associated protein 1

URI: https://gptkb.org/entity/multidrug_resistance-associated_protein_1

GPTKB entity

Statements (108)

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:MRP1
gptkbp:associatedWith	multidrug resistance in cancer
gptkbp:encodedBy	gptkb:ABCC1_gene
gptkbp:Entrez_Gene_ID	gptkb:ABCC1
gptkbp:expressedIn	gptkb:cancer gptkb:adrenal_gland gptkb:kidney gptkb:placenta gptkb:prostate gptkb:small_intestine gptkb:testis brain heart liver bone marrow colon
gptkbp:foundIn	gptkb:human gptkb:mouse right
gptkbp:function	exports drugs from cells transports organic anions
https://www.w3.org/2000/01/rdf-schema#label	multidrug resistance-associated protein 1
gptkbp:inhibitedBy	gptkb:cyclophosphamide gptkb:epigallocatechin_gallate gptkb:bleomycin gptkb:voriconazole gptkb:fluconazole gptkb:clarithromycin gptkb:ritonavir gptkb:tamoxifen gptkb:erythromycin gptkb:ketoconazole gptkb:MK-571 gptkb:busulfan gptkb:carboplatin gptkb:carmustine gptkb:chlorambucil gptkb:cladribine gptkb:cytarabine gptkb:daunorubicin gptkb:doxorubicin gptkb:fludarabine gptkb:irinotecan gptkb:lomustine gptkb:melphalan gptkb:methotrexate gptkb:mitomycin_C gptkb:mitoxantrone gptkb:oxaliplatin gptkb:pentostatin gptkb:probenecid gptkb:procarbazine gptkb:streptozotocin gptkb:temozolomide gptkb:topotecan gptkb:verapamil gptkb:cisplatin gptkb:vincristine quercetin resveratrol antineoplastic agent gemcitabine amiodarone apigenin benzbromarone curcumin cyclosporin A diltiazem dipyridamole docetaxel furosemide genistein indinavir indomethacin itraconazole kaempferol naringenin nicardipine paclitaxel posaconazole saquinavir sulfinpyrazone
gptkbp:length	1531 amino acids
gptkbp:locatedOnChromosome	16p13.1
gptkbp:location	gptkb:plasma_membrane
gptkbp:memberOf	gptkb:ATP-binding_cassette_transporter_family subfamily C
gptkbp:molecularWeight	174 kDa
gptkbp:OMIM	158343
gptkbp:PDB	5UJA
gptkbp:role	drug resistance detoxification protection against xenobiotics
gptkbp:structure	gptkb:cell_membrane
gptkbp:transportation	gptkb:daunorubicin gptkb:doxorubicin gptkb:leukotriene_C4 gptkb:methotrexate gptkb:vincristine antibiotics antiviral drugs antineoplastic agent antineoplastic agents glutathione conjugates
gptkbp:UniProtID	P33527
gptkbp:bfsParent	gptkb:C219
gptkbp:bfsLayer	5