mitomycin C

URI: https://gptkb.org/entity/mitomycin_C
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:antibiotic
natural product
antineoplastic agent
gptkbp:approvedBy gptkb:Japan
gptkbp:ATCCode L01DC03
gptkbp:brand gptkb:Mitozytrex
gptkb:Mutamycin
gptkbp:CASNumber 50-07-7
gptkbp:category antineoplastic agent
aziridine
quinone
antitumor antibiotic
lactam
gptkbp:chemicalFormula C15H18N4O5
gptkbp:discoveredBy gptkb:Kazuo_Tashiro
1956
gptkbp:eliminationHalfLife 17-50 minutes
gptkbp:excretion urine
gptkbp:first_approved_year 1958
https://www.w3.org/2000/01/rdf-schema#label mitomycin C
gptkbp:IUPACName (1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-1,1a,2,8,8a,8b-hexahydroazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7,9(6H)-trione
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction DNA crosslinking
gptkbp:meltingPoint 360 °C (decomposes)
gptkbp:metabolism liver
gptkbp:molecularWeight 334.33 g/mol
gptkbp:pregnancyCategory D (US)
gptkbp:producedBy gptkb:Streptomyces_caespitosus
gptkbp:PubChem_CID 5746
gptkbp:riskFactor carcinogenic
mutagenic
teratogenic
gptkbp:routeOfAdministration intravenous
intravesical
gptkbp:sideEffect gptkb:hemolytic_uremic_syndrome
nausea
vomiting
myelosuppression
gptkbp:solubility slightly soluble
gptkbp:UNII 50J9291LUW
gptkbp:used_in_ophthalmology to prevent pterygium recurrence
to prevent scarring after glaucoma surgery
gptkbp:usedFor pancreatic cancer
bladder cancer
cancer chemotherapy
gastric cancer
gptkbp:bfsParent gptkb:multidrug_resistance-associated_protein_1
gptkbp:bfsLayer 6