|
gptkbp:instanceOf
|
gptkb:antiviral_drug
gptkb:chemical_compound
gptkb:antineoplastic_agent
|
|
gptkbp:approvalYear
|
1969
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
L01BC01
|
|
gptkbp:brand
|
gptkb:Cytosar-U
gptkb:Depocyt
|
|
gptkbp:CASNumber
|
147-94-4
|
|
gptkbp:category
|
gptkb:antineoplastic_agent
gptkb:pyrimidine_analog
|
|
gptkbp:chemicalFormula
|
C9H13N3O5
|
|
gptkbp:discoveredBy
|
gptkb:Gertrude_Elion
gptkb:Howard_Schaeffer
gptkb:George_Hitchings
|
|
gptkbp:discoveredIn
|
1959
|
|
gptkbp:eliminationHalfLife
|
7-20 minutes (IV)
|
|
gptkbp:IUPACName
|
gptkb:4-amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
|
|
gptkbp:KEGGID
|
D00110
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits DNA synthesis
inhibits DNA polymerase
|
|
gptkbp:MeSH_ID
|
D003578
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:molecularWeight
|
243.22 g/mol
|
|
gptkbp:origin
|
sponge Cryptotethya crypta
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
6253
CHEMBL1387
DB00987
|
|
gptkbp:routeOfAdministration
|
subcutaneous
intravenous
intrathecal
|
|
gptkbp:sideEffect
|
fever
nausea
vomiting
diarrhea
rash
neurotoxicity
myelosuppression
|
|
gptkbp:synonym
|
gptkb:Ara-C
|
|
gptkbp:UNII
|
04079A1RDZ
|
|
gptkbp:usedFor
|
gptkb:chronic_myelogenous_leukemia
gptkb:leukemia
gptkb:acute_myeloid_leukemia
|
|
gptkbp:bfsParent
|
gptkb:multidrug_resistance-associated_protein_1
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
cytarabine
|