|
gptkbp:instanceOf
|
gptkb:chemical_compound
antineoplastic agent
|
|
gptkbp:approvedBy
|
1964
|
|
gptkbp:ATCCode
|
L01AA03
|
|
gptkbp:brand
|
gptkb:Alkeran
|
|
gptkbp:CASNumber
|
148-82-3
|
|
gptkbp:category
|
antineoplastic agent
cytotoxic drug
|
|
gptkbp:chemicalFormula
|
C13H18Cl2N2O2
|
|
gptkbp:color
|
white
|
|
gptkbp:contraindication
|
pregnancy
hypersensitivity to melphalan
|
|
gptkbp:discoveredBy
|
gptkb:Raymond_L._Warwick
|
|
gptkbp:eliminationHalfLife
|
1.5 hours
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:form
|
gptkb:tablet
powder for injection
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
melphalan
|
|
gptkbp:KEGGID
|
D00473
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
DNA crosslinking
|
|
gptkbp:MeSH_ID
|
D008550
|
|
gptkbp:metabolism
|
hydrolysis
|
|
gptkbp:molecularWeight
|
305.20 g/mol
|
|
gptkbp:origin
|
derivative of nitrogen mustard
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL137
4605
DB01042
|
|
gptkbp:relatedTo
|
mustard gas
|
|
gptkbp:riskFactor
|
infertility
secondary malignancies
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
vomiting
diarrhea
hair loss
bone marrow suppression
|
|
gptkbp:solubility
|
slightly soluble in water
|
|
gptkbp:storage
|
refrigerated
|
|
gptkbp:synonym
|
gptkb:L-PAM
gptkb:L-phenylalanine_mustard
gptkb:Phenylalanine_mustard
|
|
gptkbp:UNII
|
1PI7V2S4CA
|
|
gptkbp:usedFor
|
gptkb:cancer
melanoma
multiple myeloma
|
|
gptkbp:bfsParent
|
gptkb:multidrug_resistance-associated_protein_1
|
|
gptkbp:bfsLayer
|
6
|