|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:drug
|
|
gptkbp:approvedBy
|
1951
|
|
gptkbp:ATCCode
|
M04AA01
|
|
gptkbp:brand
|
gptkb:Benemid
gptkb:Probalan
|
|
gptkbp:CASNumber
|
57-66-9
|
|
gptkbp:contraindication
|
severe renal impairment
kidney stones
|
|
gptkbp:discoveredBy
|
gptkb:Laboratoires_Brocades
|
|
gptkbp:drugInteraction
|
gptkb:antibiotic
gptkb:NSAIDs
gptkb:cephalosporins
gptkb:methotrexate
indomethacin
|
|
gptkbp:eliminationHalfLife
|
4-12 hours
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:hasMolecularFormula
|
C13H19NO4S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
probenecid
|
|
gptkbp:KEGGID
|
D08410
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits renal tubular reabsorption of uric acid
uricosuric agent
|
|
gptkbp:meltingPoint
|
194-195°C
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1379
4911
4745
DB01032
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
rash
kidney stones
|
|
gptkbp:solubility
|
slightly soluble in water
|
|
gptkbp:synonym
|
4-[(dipropylamino)sulfonyl]benzoic acid
|
|
gptkbp:UNII
|
E4ES684D2P
|
|
gptkbp:usedFor
|
gout
hyperuricemia
prolonging penicillin levels
|
|
gptkbp:bfsParent
|
gptkb:MRP1
gptkb:multidrug_resistance-associated_protein_1
gptkb:famotidine
|
|
gptkbp:bfsLayer
|
6
|