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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ABCC1
gptkb:Canalicular_multispecific_organic_anion_transporter
gptkb:Multidrug_resistance_protein_1
|
|
gptkbp:associatedWith
|
gptkb:cancer
cystic fibrosis (indirectly, via ABC family)
|
|
gptkbp:cofactor
|
gptkb:ATP
|
|
gptkbp:discoveredBy
|
gptkb:Cole_et_al.
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000103222
4363
|
|
gptkbp:expressedIn
|
widely expressed in tissues
|
|
gptkbp:family
|
ATP-binding cassette transporter
|
|
gptkbp:fullName
|
gptkb:Multidrug_resistance-associated_protein_1
|
|
gptkbp:function
|
ATP-dependent transmembrane transporter
|
|
gptkbp:gene
|
gptkb:ABCC1
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:54
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MRP1
|
|
gptkbp:inhibitedBy
|
gptkb:MK-571
gptkb:probenecid
gptkb:verapamil
|
|
gptkbp:locatedOnChromosome
|
16p13.1
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
190 kDa
|
|
gptkbp:OMIM
|
158343
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Abcc1
gptkb:rat_Abcc1
|
|
gptkbp:overexpressedIn
|
associated with cancer drug resistance
|
|
gptkbp:PDB
|
5UJA
|
|
gptkbp:pharmacogenomics
|
influences drug response
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
induced by oxidative stress
regulated by Nrf2
|
|
gptkbp:role
|
multidrug resistance
|
|
gptkbp:significance
|
chemotherapy resistance
drug disposition
|
|
gptkbp:structure
|
gptkb:cell_membrane
|
|
gptkbp:subfamily
|
C subfamily
|
|
gptkbp:substrate
|
endogenous metabolites
xenobiotics
|
|
gptkbp:tissue_specificity
|
gptkb:cancer
gptkb:kidney
gptkb:placenta
gptkb:testis
brain
heart
|
|
gptkbp:transportation
|
gptkb:leukotriene_C4
antineoplastic drugs
glutathione conjugates
organic anions
|
|
gptkbp:UniProtID
|
P33527
|
|
gptkbp:bfsParent
|
gptkb:C219
|
|
gptkbp:bfsLayer
|
5
|