|
gptkbp:instanceOf
|
gptkb:chemical_compound
antineoplastic agent
|
|
gptkbp:approvedBy
|
1969
|
|
gptkbp:ATCCode
|
gptkb:L01XB05
|
|
gptkbp:brand
|
gptkb:Matulane
|
|
gptkbp:CASNumber
|
366-70-1
|
|
gptkbp:combines
|
gptkb:bleomycin
gptkb:dacarbazine
gptkb:prednisone
gptkb:doxorubicin
gptkb:lomustine
gptkb:vincristine
|
|
gptkbp:contraindication
|
pregnancy
severe renal impairment
severe hepatic impairment
|
|
gptkbp:discoveredBy
|
gptkb:Sidney_Farber
|
|
gptkbp:eliminationHalfLife
|
10 minutes
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasMolecularFormula
|
C12H19N3O
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
procarbazine
|
|
gptkbp:interactsWith
|
gptkb:beer
gptkb:tricyclic_antidepressants
gptkb:MAO_inhibitors
gptkb:sympathomimetics
barbiturates
anticoagulants
|
|
gptkbp:KEGGID
|
gptkb:D00497
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
DNA alkylation
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
221.3 g/mol
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL137
gptkb:DB01168
4911
4743
|
|
gptkbp:riskFactor
|
infertility
secondary malignancy
teratogenicity
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
anorexia
fatigue
neurotoxicity
thrombocytopenia
leukopenia
myelosuppression
|
|
gptkbp:UNII
|
S71R1Y3L9S
|
|
gptkbp:usedFor
|
Hodgkin lymphoma
brain tumors
|
|
gptkbp:bfsParent
|
gptkb:multidrug_resistance-associated_protein_1
|
|
gptkbp:bfsLayer
|
6
|