|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:antineoplastic_agent
gptkb:nitrogen_mustard
|
|
gptkbp:approvalYear
|
1957
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:L01AA02
|
|
gptkbp:brand
|
gptkb:Leukeran
|
|
gptkbp:CASNumber
|
305-03-3
|
|
gptkbp:category
|
gptkb:World_Health_Organization_essential_medicine
|
|
gptkbp:chemicalFormula
|
C14H19Cl2NO2
|
|
gptkbp:contraindication
|
pregnancy
|
|
gptkbp:discoveredBy
|
gptkb:Everett_L._May
|
|
gptkbp:eliminationHalfLife
|
1.5 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:KEGGID
|
gptkb:D00269
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
DNA crosslinking
inhibition of DNA replication
|
|
gptkbp:meltingPoint
|
178–180 °C
|
|
gptkbp:MeSH_ID
|
gptkb:D002683
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
304.22 g/mol
|
|
gptkbp:origin
|
synthetic
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1427
gptkb:DB00291
2719
|
|
gptkbp:riskFactor
|
teratogenicity
carcinogenicity
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
infertility
bone marrow suppression
secondary malignancies
|
|
gptkbp:synonym
|
gptkb:CBL
gptkb:NSC_3088
gptkb:p-[di-(2-chloroethyl)amino]benzenebutyric_acid
|
|
gptkbp:UNII
|
G1LN9045DK
|
|
gptkbp:used_in_veterinary_medicine
|
yes
|
|
gptkbp:usedFor
|
gptkb:leukemia
gptkb:Waldenström's_macroglobulinemia
Hodgkin lymphoma
chronic lymphocytic leukemia
|
|
gptkbp:bfsParent
|
gptkb:multidrug_resistance-associated_protein_1
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
chlorambucil
|