cisplatin

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
antineoplastic agent
platinum-based drug
gptkbp:approved_for_medical_use 1978
gptkbp:ATCCode L01XA01
gptkbp:CASNumber 15663-27-1
gptkbp:category gptkb:World_Health_Organization_essential_medicines
alkylating-like agent
gptkbp:chemicalFormula Cl2H6N2Pt
gptkbp:color yellow
gptkbp:discoveredBy gptkb:Michele_Peyrone
gptkbp:discoveredIn 1845
gptkbp:eliminationHalfLife 20–30 minutes (initial), 58–73 hours (terminal)
gptkbp:excretion renal
gptkbp:first_clinical_use 1971
https://www.w3.org/2000/01/rdf-schema#label cisplatin
gptkbp:IUPACName gptkb:cis-diamminedichloroplatinum(II)
gptkbp:KEGGID D00275
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction DNA crosslinking
gptkbp:meltingPoint 270°C (decomposes)
gptkbp:MeSH_ID D002945
gptkbp:metabolism non-enzymatic
gptkbp:molecularWeight 300.05 g/mol
gptkbp:pregnancyCategory D
gptkbp:PubChem_CID gptkb:CHEMBL1351
441203
DB00515
gptkbp:relatedTo gptkb:carboplatin
gptkb:oxaliplatin
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect nausea
vomiting
nephrotoxicity
neurotoxicity
ototoxicity
myelosuppression
gptkbp:solubility 2.53 g/L at 25°C
gptkbp:stateAtRoomTemperature gptkb:stone
gptkbp:synonym gptkb:CDDP
gptkb:cis-diamminedichloroplatinum(II)
gptkbp:toxicity high
gptkbp:UNII Q20Q21Q62J
gptkbp:usedFor gptkb:cancer
testicular cancer
bladder cancer
head and neck cancer
gptkbp:bfsParent gptkb:multidrug_resistance-associated_protein_1
gptkb:OCT2
gptkb:Alimta
gptkbp:bfsLayer 6