gptkbp:instanceOf
|
gptkb:chemical_compound
antineoplastic agent
platinum-based drug
|
gptkbp:approved_for_medical_use
|
1978
|
gptkbp:ATCCode
|
L01XA01
|
gptkbp:CASNumber
|
15663-27-1
|
gptkbp:category
|
gptkb:World_Health_Organization_essential_medicines
alkylating-like agent
|
gptkbp:chemicalFormula
|
Cl2H6N2Pt
|
gptkbp:color
|
yellow
|
gptkbp:discoveredBy
|
gptkb:Michele_Peyrone
|
gptkbp:discoveredIn
|
1845
|
gptkbp:eliminationHalfLife
|
20–30 minutes (initial), 58–73 hours (terminal)
|
gptkbp:excretion
|
renal
|
gptkbp:first_clinical_use
|
1971
|
https://www.w3.org/2000/01/rdf-schema#label
|
cisplatin
|
gptkbp:IUPACName
|
gptkb:cis-diamminedichloroplatinum(II)
|
gptkbp:KEGGID
|
D00275
|
gptkbp:legalStatus
|
prescription only
|
gptkbp:mechanismOfAction
|
DNA crosslinking
|
gptkbp:meltingPoint
|
270°C (decomposes)
|
gptkbp:MeSH_ID
|
D002945
|
gptkbp:metabolism
|
non-enzymatic
|
gptkbp:molecularWeight
|
300.05 g/mol
|
gptkbp:pregnancyCategory
|
D
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1351
441203
DB00515
|
gptkbp:relatedTo
|
gptkb:carboplatin
gptkb:oxaliplatin
|
gptkbp:routeOfAdministration
|
intravenous
|
gptkbp:sideEffect
|
nausea
vomiting
nephrotoxicity
neurotoxicity
ototoxicity
myelosuppression
|
gptkbp:solubility
|
2.53 g/L at 25°C
|
gptkbp:stateAtRoomTemperature
|
gptkb:stone
|
gptkbp:synonym
|
gptkb:CDDP
gptkb:cis-diamminedichloroplatinum(II)
|
gptkbp:toxicity
|
high
|
gptkbp:UNII
|
Q20Q21Q62J
|
gptkbp:usedFor
|
gptkb:cancer
testicular cancer
bladder cancer
head and neck cancer
|
gptkbp:bfsParent
|
gptkb:multidrug_resistance-associated_protein_1
gptkb:OCT2
gptkb:Alimta
|
gptkbp:bfsLayer
|
6
|