|
gptkbp:instanceOf
|
gptkb:drug
antineoplastic agent
immunosuppressant
|
|
gptkbp:antidote
|
gptkb:leucovorin
|
|
gptkbp:approvedBy
|
1953
|
|
gptkbp:ATCCode
|
L01BA01
|
|
gptkbp:brand
|
gptkb:Otrexup
gptkb:Rheumatrex
gptkb:Trexall
Rasuvo
|
|
gptkbp:CASNumber
|
59-05-2
|
|
gptkbp:chemicalFormula
|
C20H22N8O5
|
|
gptkbp:contraindication
|
gptkb:liver_disease
alcoholism
pregnancy
|
|
gptkbp:discoveredBy
|
gptkb:Sidney_Farber
|
|
gptkbp:discoveredIn
|
1947
|
|
gptkbp:eliminationHalfLife
|
3-10 hours
|
|
gptkbp:excretion
|
kidneys
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
methotrexate
|
|
gptkbp:includedIn
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:KEGGID
|
D00133
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits dihydrofolate reductase
|
|
gptkbp:MeSH_ID
|
D008785
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
454.45 g/mol
|
|
gptkbp:pregnancyCategory
|
X
|
|
gptkbp:PubChem_CID
|
126941
CHEBI:44185
DB00563
|
|
gptkbp:routeOfAdministration
|
oral
intramuscular
subcutaneous
intravenous
|
|
gptkbp:sideEffect
|
nausea
fatigue
hair loss
liver toxicity
bone marrow suppression
mouth ulcers
|
|
gptkbp:UNII
|
YL5FZ2Y5U1
|
|
gptkbp:usedFor
|
gptkb:cancer
gptkb:systemic_lupus_erythematosus
gptkb:Crohn's_disease
psoriasis
rheumatoid arthritis
ectopic pregnancy
|
|
gptkbp:bfsParent
|
gptkb:ABCC1
gptkb:multidrug_resistance-associated_protein_1
gptkb:ibuprofen
gptkb:NSAID
gptkb:omeprazole
gptkb:pantoprazole
gptkb:Rituxan
gptkb:juvenile_dermatomyositis
gptkb:paraneoplastic_dermatomyositis
gptkb:Folinic_acid
gptkb:trimethoprim-sulfamethoxazole
|
|
gptkbp:bfsLayer
|
6
|