|
gptkbp:instanceOf
|
gptkb:antibiotic
antineoplastic agent
|
|
gptkbp:administeredBy
|
intramuscular injection
subcutaneous injection
intravenous injection
|
|
gptkbp:approvedBy
|
1973 (US)
|
|
gptkbp:ATCCode
|
L01DC01
|
|
gptkbp:brand
|
gptkb:Blenoxane
|
|
gptkbp:CASNumber
|
11056-06-7
|
|
gptkbp:chemicalFormula
|
C55H84N17O21S3
|
|
gptkbp:combines
|
gptkb:doxorubicin
gptkb:cisplatin
gptkb:vinblastine
antineoplastic agent
|
|
gptkbp:contraindication
|
hypersensitivity to bleomycin
|
|
gptkbp:discoveredBy
|
gptkb:Hamao_Umezawa
|
|
gptkbp:discoveredIn
|
1966
|
|
gptkbp:eliminationHalfLife
|
2-4 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
bleomycin
|
|
gptkbp:includedIn
|
gptkb:World_Health_Organization's_List_of_Essential_Medicines
|
|
gptkbp:KEGGID
|
D07513
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
induces DNA strand breaks
|
|
gptkbp:metabolism
|
gptkb:bleomycin_hydrolase
|
|
gptkbp:molecularWeight
|
1415.6 g/mol
|
|
gptkbp:monitors
|
liver function
renal function
pulmonary function
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:producedBy
|
gptkb:Streptomyces_verticillus
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1082
5360373
|
|
gptkbp:riskFactor
|
age over 70
pre-existing lung disease
|
|
gptkbp:routeOfAdministration
|
intramuscular
subcutaneous
intravenous
intrapleural
|
|
gptkbp:sideEffect
|
fever
alopecia
pulmonary fibrosis
rash
mucositis
|
|
gptkbp:UNII
|
40M16D6NTS
|
|
gptkbp:usedFor
|
gptkb:cancer
testicular cancer
Hodgkin lymphoma
|
|
gptkbp:bfsParent
|
gptkb:multidrug_resistance-associated_protein_1
gptkb:Nippon_Kayaku
|
|
gptkbp:bfsLayer
|
6
|