temozolomide

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf antineoplastic agent
gptkbp:administeredBy radiotherapy
gptkbp:approvalYear 1999
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode L01AX03
gptkbp:bioavailability 100%
gptkbp:brand gptkb:Temodal
gptkb:Temodar
gptkbp:CASNumber 85622-93-1
gptkbp:category antineoplastic agent
imidazotetrazine derivative
gptkbp:chemicalFormula C6H6N6O2
gptkbp:contraindication severe myelosuppression
hypersensitivity to temozolomide
gptkbp:developedBy gptkb:Schering-Plough
gptkbp:discoveredBy gptkb:Malcolm_Stevens
gptkbp:eliminationHalfLife 1.8 hours
gptkbp:excretion urine
gptkbp:firstSynthesized 1987
https://www.w3.org/2000/01/rdf-schema#label temozolomide
gptkbp:interactsWith gptkb:phenytoin
gptkb:valproic_acid
gptkb:carbamazepine
live vaccines
gptkbp:KEGGID D06053
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction DNA methylation
gptkbp:metabolism liver
gptkbp:molecularWeight 194.15 g/mol
gptkbp:origin gptkb:United_Kingdom
gptkbp:pregnancyCategory D (US)
gptkbp:prodrugOf MTIC (5-(3-methyltriazen-1-yl)imidazole-4-carboxamide)
gptkbp:proteinBinding 10-20%
gptkbp:PubChem_CID gptkb:CHEMBL606
5394
DB00853
gptkbp:riskFactor immunosuppression
teratogenicity
secondary malignancies
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
vomiting
fatigue
myelosuppression
gptkbp:solubility 3.3 mg/mL
gptkbp:storage room temperature
gptkbp:UNII JEP0YGT94R
gptkbp:usedFor gptkb:glioblastoma_multiforme
gptkb:anaplastic_astrocytoma
gptkbp:bfsParent gptkb:multidrug_resistance-associated_protein_1
gptkb:Stupp_protocol
gptkb:glioblastoma_multiforme
gptkbp:bfsLayer 6