|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:MRP1
|
|
gptkbp:associatedWith
|
multidrug resistance
oxidative stress response
inflammatory response
cystic fibrosis (indirectly, as related to ABCC family)
cancer drug resistance
|
|
gptkbp:ATPBindingDomains
|
2
|
|
gptkbp:discoveredBy
|
gptkb:Cole_et_al.
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodes
|
gptkb:Multidrug_resistance-associated_protein_1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000103222
4363
|
|
gptkbp:expressedIn
|
various tissues including lung, testis, and kidney
|
|
gptkbp:function
|
transports organic anions and drugs out of cells
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:53
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ABCC1
|
|
gptkbp:length
|
1531 amino acids
|
|
gptkbp:locatedOnChromosome
|
16
|
|
gptkbp:memberOf
|
gptkb:ATP-binding_cassette_transporter_family
subfamily C
|
|
gptkbp:mutationAssociatedWith
|
can affect susceptibility to toxins
can alter drug pharmacokinetics
can confer resistance to chemotherapy
|
|
gptkbp:OMIM
|
158343
|
|
gptkbp:orthologInC.elegans
|
mrp-1
|
|
gptkbp:orthologInDrosophila
|
gptkb:MRP
|
|
gptkbp:orthologInMouse
|
gptkb:Abcc1
|
|
gptkbp:orthologInYeast
|
gptkb:YCF1
|
|
gptkbp:product
|
gptkb:cell_membrane
|
|
gptkbp:publicTransit
|
ABC transporter
|
|
gptkbp:regulates
|
induced by oxidative stress
regulated by Nrf2
regulated by hypoxia
regulated by p53
|
|
gptkbp:transmembraneDomains
|
17
|
|
gptkbp:transportation
|
gptkb:daunorubicin
gptkb:doxorubicin
gptkb:leukotriene_C4
gptkb:methotrexate
gptkb:vincristine
antibiotics
antiviral drugs
antineoplastic agent
antineoplastic agents
cyclic nucleotides
glutathione conjugates
organic anions
|
|
gptkbp:UniProtID
|
P33527
|
|
gptkbp:bfsParent
|
gptkb:C219
|
|
gptkbp:bfsLayer
|
5
|