doxorubicin

URI: https://gptkb.org/entity/doxorubicin

GPTKB entity

Statements (54)

Predicate	Object
gptkbp:instanceOf	antineoplastic agent anthracycline antibiotic
gptkbp:approvedBy	1974 (US)
gptkbp:ATCCode	L01DB01
gptkbp:brand	gptkb:Adriamycin gptkb:Doxil
gptkbp:CASNumber	23214-92-8
gptkbp:chemicalFormula	C27H29NO11
gptkbp:color	red-orange
gptkbp:contraindication	hypersensitivity to doxorubicin severe cardiac impairment
gptkbp:discoveredBy	gptkb:Farmitalia
gptkbp:discoveredIn	1967
gptkbp:eliminationHalfLife	20-48 hours
gptkbp:excretion	urine bile
https://www.w3.org/2000/01/rdf-schema#label	doxorubicin
gptkbp:IUPACName	(8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
gptkbp:KEGGID	D00141
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	inhibits topoisomerase II intercalates DNA
gptkbp:meltingPoint	205°C
gptkbp:metabolism	liver
gptkbp:molecularWeight	543.52 g/mol
gptkbp:origin	gptkb:Streptomyces_peucetius
gptkbp:pregnancyCategory	D (US)
gptkbp:pregnancyRisk	teratogenic
gptkbp:proteinBinding	74-76%
gptkbp:PubChem_CID	31703 CHEMBL53453 DB00997
gptkbp:routeOfAdministration	intravenous
gptkbp:sideEffect	nausea vomiting hair loss cardiotoxicity mucositis myelosuppression
gptkbp:solubility	water soluble
gptkbp:synonym	gptkb:hydroxydaunorubicin gptkb:DOX
gptkbp:toxicity	cardiotoxic
gptkbp:UNII	80168379AG
gptkbp:usedFor	gptkb:cancer gptkb:rhabdomyosarcoma leukemia bladder cancer
gptkbp:WHOModelListOfEssentialMedicines	included
gptkbp:bfsParent	gptkb:ABCC1 gptkb:multidrug_resistance-associated_protein_1 gptkb:Type_II_topoisomerase gptkb:topoisomerase_II
gptkbp:bfsLayer	6