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gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
gptkb:aspartate
|
|
gptkbp:alternativeName
|
gptkb:gamma-secretase_complex
presenilin complex
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:PSEN1
gptkb:PSEN2
APH1A
APH1B
NCSTN
PEN2
|
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gptkbp:composedOf
|
gptkb:APH-1
gptkb:PEN-2
gptkb:nicastrin
presenilin
|
|
gptkbp:discoveredBy
|
gptkb:Bart_De_Strooper
|
|
gptkbp:EC_number
|
3.4.23.46
|
|
gptkbp:function
|
cleavage of Notch receptor
cleavage of amyloid precursor protein
intramembrane proteolysis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
gamma-secretase
|
|
gptkbp:inhibitedBy
|
DAPT
LY-411,575
semagacestat
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
gptkb:cell_membrane
gptkb:Golgi_apparatus
|
|
gptkbp:molecularWeight
|
~230 kDa
|
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gptkbp:substrate
|
gptkb:LRP1
gptkb:CD46
gptkb:p75NTR
gptkb:DCC
gptkb:EphB2
gptkb:TREM2
gptkb:p75_neurotrophin_receptor
gptkb:CD44
gptkb:Nectin-4
gptkb:sortilin
gptkb:E-cadherin
gptkb:Notch_receptor
gptkb:Ephrin_receptors
gptkb:N-cadherin
gptkb:CD99
gptkb:amyloid_precursor_protein
gptkb:LRP1B
gptkb:Jagged1
gptkb:TREM1
gptkb:CD43
CD44 antigen
ErbB2
ErbB3
ErbB4
neuregulin-1
APP-like protein 1
APP-like protein 2
CD99 antigen
Delta-like 1
Desmocollin-1
Desmocollin-2
Desmocollin-3
Desmoglein-1
Desmoglein-2
Desmoglein-3
EphA4
Nectin-1
Nectin-2
Nectin-3
SorLA
TREM3
cadherin-23
protocadherin-10
protocadherin-12
protocadherin-15
protocadherin-18
protocadherin-19
protocadherin-20
protocadherin-21
protocadherin-22
protocadherin-23
protocadherin-24
protocadherin-25
protocadherin-26
protocadherin-27
protocadherin-28
protocadherin-29
protocadherin-30
protocadherin-8
syndecan-1
syndecan-2
syndecan-3
syndecan-4
|
|
gptkbp:bfsParent
|
gptkb:Notch_protein
gptkb:Notch_signaling_pathway
gptkb:Amyloid_beta_A4_protein
gptkb:Notch_receptor
gptkb:EpCAM
|
|
gptkbp:bfsLayer
|
7
|