p75 neurotrophin receptor

URI: https://gptkb.org/entity/p75_neurotrophin_receptor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:cell_surface_receptor
gptkbp:alternativeName	gptkb:NGFR gptkb:CD271 gptkb:TNFRSF16
gptkbp:associatedWith	gptkb:Alzheimer's_disease gptkb:glioma nerve injury
gptkbp:binds	gptkb:nerve_growth_factor gptkb:brain-derived_neurotrophic_factor gptkb:neurotrophin-3 gptkb:neurotrophin-4
gptkbp:domain	transmembrane domain extracellular cysteine-rich domain intracellular death domain
gptkbp:encodedBy	gptkb:NGFR_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000120656 4804
gptkbp:expressedIn	development central nervous system peripheral nervous system
gptkbp:firstDescribed	1986
gptkbp:foundIn	gptkb:neurons glial cells Schwann cells
gptkbp:function	regulates apoptosis regulates axonal growth regulates myelination regulates neuronal survival
gptkbp:HGNC_ID	7808
gptkbp:interactsWith	gptkb:Nogo_receptor gptkb:TrkA_receptor gptkb:sortilin
gptkbp:involvedIn	gptkb:synaptic_plasticity neurite outgrowth neuronal differentiation cell death axon pruning
gptkbp:length	427 amino acids
gptkbp:locatedOnChromosome	gptkb:17q21
gptkbp:memberOf	gptkb:tumor_necrosis_factor_receptor_superfamily
gptkbp:modulatedBy	neurotrophin signaling
gptkbp:molecularWeight	45 kDa
gptkbp:OMIM	162010
gptkbp:structure	single-pass type I membrane protein
gptkbp:UniProtID	gptkb:P08138
gptkbp:bfsParent	gptkb:p75NTR
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	p75 neurotrophin receptor