p75 neurotrophin receptor

URI: https://gptkb.org/entity/p75_neurotrophin_receptor
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
cell surface receptor
gptkbp:alternativeName gptkb:NGFR
gptkb:CD271
gptkb:TNFRSF16
gptkbp:associatedWith gptkb:Alzheimer's_disease
nerve injury
glioma
gptkbp:binds gptkb:nerve_growth_factor
gptkb:brain-derived_neurotrophic_factor
gptkb:neurotrophin-3
gptkb:neurotrophin-4
gptkbp:domain transmembrane domain
extracellular cysteine-rich domain
intracellular death domain
gptkbp:encodedBy gptkb:NGFR_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000120656
4804
gptkbp:expressedIn development
central nervous system
peripheral nervous system
gptkbp:firstDescribed 1986
gptkbp:foundIn neurons
glial cells
Schwann cells
gptkbp:function regulates apoptosis
regulates axonal growth
regulates myelination
regulates neuronal survival
gptkbp:HGNC_ID 7808
https://www.w3.org/2000/01/rdf-schema#label p75 neurotrophin receptor
gptkbp:interactsWith gptkb:Nogo_receptor
gptkb:TrkA_receptor
gptkb:sortilin
gptkbp:involvedIn gptkb:synaptic_plasticity
neurite outgrowth
neuronal differentiation
cell death
axon pruning
gptkbp:length 427 amino acids
gptkbp:locatedOnChromosome gptkb:17q21
gptkbp:memberOf gptkb:tumor_necrosis_factor_receptor_superfamily
gptkbp:modulatedBy neurotrophin signaling
gptkbp:molecularWeight 45 kDa
gptkbp:OMIM 162010
gptkbp:structure single-pass type I membrane protein
gptkbp:UniProtID gptkb:P08138
gptkbp:bfsParent gptkb:p75NTR
gptkb:Rabies_virus
gptkbp:bfsLayer 6