|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:membrane_cofactor_protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:antigen
|
yes
|
|
gptkbp:associatedWith
|
gptkb:atypical_hemolytic_uremic_syndrome
gptkb:systemic_lupus_erythematosus
pre-eclampsia
|
|
gptkbp:cellularComponent
|
gptkb:cell_membrane
|
|
gptkbp:component
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Peter_J_Lachmann
|
|
gptkbp:domain
|
CCP domain
serine/threonine-rich domain
|
|
gptkbp:encodedBy
|
gptkb:CD46_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000117335
|
|
gptkbp:expressedIn
|
many human tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
cofactor for factor I-mediated cleavage of C3b and C4b
complement binding
regulation of complement activation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
immune response
|
|
gptkbp:hasIsoform
|
CD46-001
CD46-002
CD46-003
|
|
gptkbp:hasPolymorphism
|
yes
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6953
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD46
|
|
gptkbp:interactsWith
|
gptkb:virus
gptkb:Neisseria_gonorrhoeae
gptkb:measles_virus
|
|
gptkbp:length
|
350 amino acids (canonical isoform)
|
|
gptkbp:locatedOn
|
chromosome 1
|
|
gptkbp:locatedOnChromosome
|
1q32
|
|
gptkbp:molecularWeight
|
45-66 kDa
|
|
gptkbp:OMIM
|
120900
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
|
|
gptkbp:PDB
|
3O8E
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
gptkb:NM_002389
|
|
gptkbp:regulates
|
complement system
|
|
gptkbp:relatedTo
|
gptkb:disease
immunology
|
|
gptkbp:structure
|
type I membrane protein
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
gptkb:P15529
|
|
gptkbp:usedAs
|
receptor for pathogens
|
|
gptkbp:bfsParent
|
gptkb:chromosome_1q32
|
|
gptkbp:bfsLayer
|
7
|