Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abnormalFunctionAssociatedWith |
neurodevelopmental disorders
tumorigenesis angiogenic diseases |
| gptkbp:alsoKnownAs |
Eph receptors
|
| gptkbp:category |
gptkb:cell_membrane
gptkb:receptor_tyrosine_kinases cell surface receptor |
| gptkbp:database |
gptkb:NCBI_Gene
gptkb:HGNC gptkb:UniProt |
| gptkbp:discoveredBy |
Nobumasa Takahashi
|
| gptkbp:firstDescribed |
1990s
|
| gptkbp:foundIn |
invertebrates
vertebrates |
| gptkbp:function |
angiogenesis
cell migration cell signaling axon guidance |
| https://www.w3.org/2000/01/rdf-schema#label |
Ephrin receptors
|
| gptkbp:ligand |
ephrins
|
| gptkbp:locatedOnChromosome |
various chromosomes
|
| gptkbp:mechanismOfAction |
bidirectional signaling
contact-dependent signaling |
| gptkbp:member |
gptkb:EPHA2
gptkb:EPHA4 gptkb:EPHA5 gptkb:EPHA6 gptkb:EPHA7 gptkb:EPHA8 gptkb:EPHA3 gptkb:EPHA1 EPHB3 EPHB1 EPHB2 EPHB4 EPHB6 |
| gptkbp:role |
cancer progression
nervous system development vascular development tissue boundary formation |
| gptkbp:structure |
extracellular domain
transmembrane domain intracellular tyrosine kinase domain |
| gptkbp:subfamily |
EphA receptors
EphB receptors |
| gptkbp:target |
therapeutic drugs
|
| gptkbp:bfsParent |
gptkb:PTPRB
|
| gptkbp:bfsLayer |
7
|