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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:abnormalFunctionAssociatedWith
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neurodevelopmental disorders
tumorigenesis
angiogenic diseases
|
|
gptkbp:alsoKnownAs
|
Eph receptors
|
|
gptkbp:category
|
gptkb:cell_membrane
gptkb:cell_surface_receptor
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:database
|
gptkb:NCBI_Gene
gptkb:HGNC
gptkb:UniProt
|
|
gptkbp:discoveredBy
|
Nobumasa Takahashi
|
|
gptkbp:firstDescribed
|
1990s
|
|
gptkbp:foundIn
|
invertebrates
vertebrates
|
|
gptkbp:function
|
angiogenesis
cell migration
cell signaling
axon guidance
|
|
gptkbp:ligand
|
ephrins
|
|
gptkbp:locatedOnChromosome
|
various chromosomes
|
|
gptkbp:mechanismOfAction
|
bidirectional signaling
contact-dependent signaling
|
|
gptkbp:member
|
gptkb:EPHA2
gptkb:EPHA4
gptkb:EPHA5
gptkb:EPHA6
gptkb:EPHA7
gptkb:EPHA8
gptkb:EPHA3
gptkb:EPHA1
EPHB3
EPHB1
EPHB2
EPHB4
EPHB6
|
|
gptkbp:role
|
cancer progression
nervous system development
vascular development
tissue boundary formation
|
|
gptkbp:structure
|
extracellular domain
transmembrane domain
intracellular tyrosine kinase domain
|
|
gptkbp:subfamily
|
EphA receptors
EphB receptors
|
|
gptkbp:target
|
therapeutic drugs
|
|
gptkbp:bfsParent
|
gptkb:PTPRB
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ephrin receptors
|