|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
CD354
|
|
gptkbp:associatedWith
|
sepsis
inflammatory diseases
|
|
gptkbp:biologicalProcess
|
receptor activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:downregulatedIn
|
anti-inflammatory cytokines
|
|
gptkbp:encodedBy
|
gptkb:TREM1_gene
|
|
gptkbp:Entrez_Gene_ID
|
54210
ENSG00000124731
|
|
gptkbp:expressedIn
|
myeloid cells
monocytes
neutrophils
|
|
gptkbp:extracellularDomain
|
present
|
|
gptkbp:fullName
|
Triggering receptor expressed on myeloid cells 1
|
|
gptkbp:function
|
amplifies inflammatory responses
modulates innate immune response
|
|
gptkbp:gene
|
gptkb:TREM1
|
|
gptkbp:hasBiomarker
|
sepsis severity
|
|
gptkbp:HGNC_ID
|
17762
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TREM1
|
|
gptkbp:interactsWith
|
gptkb:DAP12
|
|
gptkbp:involves
|
gptkb:cancer
cardiovascular diseases
autoimmune diseases
chronic inflammatory diseases
acute inflammatory response
|
|
gptkbp:length
|
234 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
|
|
gptkbp:modulatedBy
|
gptkb:NF-kappaB_pathway
TLR signaling
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:proteinFamily
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:regulates
|
cytokine production
chemokine production
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:solubleForm
|
sTREM1
|
|
gptkbp:solubleFormDetectedIn
|
gptkb:plasma
serum
body fluids
|
|
gptkbp:structure
|
single-pass type I membrane protein
|
|
gptkbp:target
|
anti-inflammatory therapies
|
|
gptkbp:transmembraneDomains
|
present
|
|
gptkbp:UniProtID
|
Q9NP99
|
|
gptkbp:upregulatedBy
|
gptkb:Bacteria
fungal infection
|
|
gptkbp:bfsParent
|
gptkb:CD280
gptkb:gamma-secretase
|
|
gptkbp:bfsLayer
|
8
|