|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
ligand binding
|
|
gptkbp:cleavage
|
gptkb:gamma-secretase
|
|
gptkbp:component
|
gptkb:Notch_signaling_pathway
|
|
gptkbp:discoveredIn
|
gptkb:Drosophila_melanogaster
|
|
gptkbp:domain
|
EGF-like repeats
ankyrin repeats
|
|
gptkbp:encodedBy
|
gptkb:NOTCH3_gene
gptkb:NOTCH1_gene
gptkb:NOTCH2_gene
gptkb:NOTCH4_gene
|
|
gptkbp:firstDescribed
|
1917
|
|
gptkbp:foundIn
|
animals
|
|
gptkbp:function
|
cell signaling
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Notch receptor
|
|
gptkbp:involvedIn
|
angiogenesis
cell fate determination
neurogenesis
stem cell maintenance
developmental processes
|
|
gptkbp:ligand
|
gptkb:Jagged
Delta
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:CADASIL
gptkb:Alagille_syndrome
gptkb:T-cell_acute_lymphoblastic_leukemia
|
|
gptkbp:namedAfter
|
notched wing phenotype in Drosophila
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
|
|
gptkbp:structure
|
single-pass transmembrane protein
|
|
gptkbp:bfsParent
|
gptkb:ADAM17
|
|
gptkbp:bfsLayer
|
6
|