amyloid precursor protein

URI: https://gptkb.org/entity/amyloid_precursor_protein

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:APP
gptkbp:alternativeSplicing	gptkb:APP695 gptkb:APP751 gptkb:APP770
gptkbp:category	gptkb:cell_membrane single-pass transmembrane protein
gptkbp:cleavage	gptkb:alpha-secretase gptkb:beta-secretase gptkb:gamma-secretase
gptkbp:discoveredBy	Allan D. Roses
gptkbp:discoveredIn	1987
gptkbp:encodedBy	gptkb:APP_gene
gptkbp:Entrez_Gene_ID	351
gptkbp:expressedIn	gptkb:skeletal_muscle brain other tissues
gptkbp:foundIn	gptkb:human gptkb:mouse other mammals
gptkbp:function	cell adhesion neuronal growth synaptic formation precursor of amyloid beta
gptkbp:HGNC_ID	620
gptkbp:interactsWith	gptkb:ApoE gptkb:BACE1 gptkb:presenilin-1 gptkb:Fe65 gptkb:nicastrin gptkb:X11
gptkbp:involvedIn	gptkb:synaptic_plasticity gptkb:axonal_transport neuronal migration
gptkbp:locatedOnChromosome	chromosome 21
gptkbp:location	gptkb:cell_membrane
gptkbp:molecularWeight	~100-140 kDa
gptkbp:mutationAssociatedWith	gptkb:familial_Alzheimer's_disease
gptkbp:OMIM	104760
gptkbp:orthologIn	mouse APP rat APP zebrafish APP
gptkbp:PDB	gptkb:1AAP 2LLM 3UMH
gptkbp:postTranslationalModification	palmitoylation phosphorylation glycosylation
gptkbp:relatedTo	gptkb:Alzheimer's_disease
gptkbp:UniProtID	gptkb:P05067
gptkbp:bfsParent	gptkb:LRP1 gptkb:amyloid_beta_protein
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	amyloid precursor protein