|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Nasu-Hakola_disease
frontotemporal dementia
|
|
gptkbp:biologicalProcess
|
cell signaling
immune response
receptor activity
regulation of inflammatory response
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:encodedBy
|
gptkb:TREM2_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000095970
|
|
gptkbp:expressedIn
|
gptkb:microglia
macrophages
|
|
gptkbp:extracellularDomain
|
yes
|
|
gptkbp:fullName
|
gptkb:Triggering_receptor_expressed_on_myeloid_cells_2
|
|
gptkbp:function
|
phagocytosis
immune receptor
modulation of inflammation
regulation of microglial activity
|
|
gptkbp:gene
|
gptkb:TREM2
|
|
gptkbp:glycosylation
|
yes
|
|
gptkbp:HGNC_ID
|
17761
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TREM2
|
|
gptkbp:interactsWith
|
gptkb:DAP12
|
|
gptkbp:length
|
230
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
|
|
gptkbp:molecularWeight
|
25 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased risk of neurodegeneration
|
|
gptkbp:OMIM
|
605086
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Trem2
|
|
gptkbp:PDB
|
gptkb:5ELI
|
|
gptkbp:phosphorylates
|
yes
|
|
gptkbp:proteinFamily
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:HGNC
gptkb:OMIM
gptkb:UniProt
gptkb:Ensembl
gptkb:Human_Protein_Atlas
gptkb:Alzforum
|
|
gptkbp:signalPeptide
|
yes
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
gptkb:Q9NZC2
|
|
gptkbp:bfsParent
|
gptkb:microglia
|
|
gptkbp:bfsLayer
|
6
|