|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:CD91
gptkb:alpha-2-macroglobulin_receptor
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
atherosclerosis
|
|
gptkbp:biologicalProcess
|
signal transduction
cell migration
lipid transport
endocytosis
receptor activity
protein binding
lipoprotein particle binding
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
endocytic vesicle
|
|
gptkbp:discoveredBy
|
gptkb:Richard_L._Huganir
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodes
|
gptkb:LRP1_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000123384
4035
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
brain
liver
vascular smooth muscle cells
|
|
gptkbp:fullName
|
gptkb:Low-density_lipoprotein_receptor-related_protein_1
|
|
gptkbp:function
|
cell signaling
regulation of lipid homeostasis
endocytosis of various ligands
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
6692
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LRP1
|
|
gptkbp:interactsWith
|
gptkb:tissue_plasminogen_activator
gptkb:APOE
gptkb:alpha-2-macroglobulin
gptkb:amyloid_precursor_protein
|
|
gptkbp:length
|
4544 amino acids
|
|
gptkbp:locatedOnChromosome
|
12q13.3
|
|
gptkbp:OMIM
|
107770
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Lrp1
|
|
gptkbp:PDB
|
gptkb:2FCW
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:product
|
single-pass type I membrane protein
|
|
gptkbp:proteinFamily
|
gptkb:LDL_receptor_family
|
|
gptkbp:UniProtID
|
gptkb:Q07954
|
|
gptkbp:bfsParent
|
gptkb:LDL_receptor
|
|
gptkbp:bfsLayer
|
6
|