Statements (69)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:neurodegenerative_diseases
cognitive decline apoptosis biomarker discovery cell cycle regulation cell proliferation cellular homeostasis clinical trials drug development mitochondrial function neurotransmitter release signal transduction therapeutic interventions neuroinflammation cell survival synaptic plasticity differentiation calcium signaling protein degradation behavioral changes gene expression regulation cellular signaling pathways neurodegeneration autophagy reactive oxygen species tau pathology protein-protein interactions neurotrophic factors lipid rafts research advancements intracellular signaling axon guidance cellular stress responses protein aggregation memory impairment endosomal trafficking extracellular matrix interactions gamma-secretase inhibitors synaptic dysfunction APP processing abnormalities Notch signaling dysregulation gamma-secretase modulators membrane microdomains presenilin mutations |
| gptkbp:clinical_trial |
implicated in cancer biology
target for Alzheimer's therapy |
| gptkbp:composed_of |
APH-1
PEN-2 nicastrin presenilin |
| gptkbp:discovered_by |
1990s
|
| gptkbp:function |
cleaves transmembrane proteins
|
| gptkbp:fuselage_material |
gptkb:Notch
amyloid precursor protein |
| https://www.w3.org/2000/01/rdf-schema#label |
gamma-secretase complex
|
| gptkbp:initiated_by |
avagacestat
begacestat semagacestat ELND006 |
| gptkbp:involved_in |
gptkb:neurodegenerative_diseases
Notch signaling pathway |
| gptkbp:location |
cell membrane
|
| gptkbp:role |
influencing synaptic function
processing of APP regulating cell signaling regulating neuronal development |
| gptkbp:bfsParent |
gptkb:PSEN2
|
| gptkbp:bfsLayer |
8
|