|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
presenilin complex
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:PSEN1
gptkb:PSEN2
APH1A
APH1B
NCSTN
PSENEN
|
|
gptkbp:biologicalProcess
|
aspartyl protease activity
|
|
gptkbp:catalyzes
|
cleavage of Notch receptor
cleavage of amyloid precursor protein
|
|
gptkbp:composedOf
|
gptkb:APH-1
gptkb:PEN-2
gptkb:nicastrin
presenilin
|
|
gptkbp:determines
|
cryo-electron microscopy
|
|
gptkbp:discoveredBy
|
gptkb:Bart_De_Strooper
gptkb:Christian_Haass
|
|
gptkbp:EC_number
|
3.4.23.46
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
intramembrane proteolysis
|
|
gptkbp:GO_term
|
GO:0004252
|
|
gptkbp:hasBiologicalActivity
|
gamma-secretase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
gamma-secretase complex
|
|
gptkbp:inhibitedBy
|
DAPT
semagacestat
|
|
gptkbp:involvedIn
|
cell signaling
Notch receptor processing
amyloid-beta formation
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
gptkb:cell_membrane
gptkb:Golgi_apparatus
|
|
gptkbp:molecularWeight
|
~230 kDa
|
|
gptkbp:OMIM
|
607822
|
|
gptkbp:PDB
|
5A63
5FN2
6IYC
|
|
gptkbp:Reactome
|
R-HSA-1912422
|
|
gptkbp:relatedTo
|
gptkb:Notch_signaling_pathway
gptkb:familial_Alzheimer's_disease
|
|
gptkbp:subunit
|
gptkb:presenilin-1
gptkb:presenilin-2
gptkb:PEN-2
gptkb:nicastrin
APH-1A
APH-1B
|
|
gptkbp:UniProtID
|
Q9Y5Q9
|
|
gptkbp:bfsParent
|
gptkb:P49763
gptkb:PSEN1
gptkb:presenilin-1
gptkb:gamma-secretase
|
|
gptkbp:bfsLayer
|
8
|