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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:APP
gptkb:Amyloid_precursor_protein
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
|
|
gptkbp:cellularComponent
|
gptkb:endosome
gptkb:Golgi_apparatus
gptkb:plasma_membrane
extracellular space
|
|
gptkbp:cleavage
|
gptkb:beta-secretase
gptkb:gamma-secretase
|
|
gptkbp:encodedBy
|
gptkb:APP_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000142192
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
other tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
cell surface receptor
cell adhesion
protein binding
heparin binding
neuronal growth
synaptic formation
|
|
gptkbp:GOProcess
|
gptkb:synaptic_plasticity
cell adhesion
axonogenesis
neuron migration
|
|
gptkbp:HGNC_ID
|
gptkb:APP
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Amyloid beta A4 protein
|
|
gptkbp:locatedOnChromosome
|
chromosome 21
21q21.3
|
|
gptkbp:molecularWeight
|
~100-140 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Down_syndrome
gptkb:familial_Alzheimer's_disease
|
|
gptkbp:OMIM
|
104760
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Pan_troglodytes
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1AAP
2LLM
3UMH
|
|
gptkbp:postTranslationalModification
|
palmitoylation
phosphorylation
glycosylation
sulfation
|
|
gptkbp:predecessor
|
gptkb:amyloid_beta_peptide
|
|
gptkbp:RefSeq
|
NP_000475.1
|
|
gptkbp:UniProtID
|
gptkb:P05067
|
|
gptkbp:bfsParent
|
gptkb:P35637
|
|
gptkbp:bfsLayer
|
6
|