|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Neural_cadherin
gptkb:CDH2
|
|
gptkbp:antibodyAvailable
|
yes
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:CDH2_gene
|
|
gptkbp:expressedIn
|
embryonic development
cardiac muscle
neurons
endothelial cells
fibroblasts
|
|
gptkbp:form
|
homodimers
adherens junctions
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
neural development
cell adhesion
calcium ion binding
cell-cell adhesion
synapse formation
tissue morphogenesis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
N-cadherin
|
|
gptkbp:interactsWith
|
gptkb:alpha-catenin
gptkb:p120-catenin
gptkb:beta-catenin
|
|
gptkbp:involvedIn
|
wound healing
angiogenesis
axon guidance
tumor progression
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_18q12.1
|
|
gptkbp:marking
|
epithelial-mesenchymal transition
mesenchymal cells
|
|
gptkbp:memberOf
|
gptkb:cadherin_family
|
|
gptkbp:molecularWeight
|
~130 kDa
|
|
gptkbp:mutationAssociatedWith
|
neurodevelopmental disorders
arrhythmogenic right ventricular cardiomyopathy
|
|
gptkbp:OMIM
|
114020
|
|
gptkbp:PDB
|
1NCI
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:role
|
gptkb:synaptic_plasticity
cardiac development
epithelial-mesenchymal transition
cancer metastasis
|
|
gptkbp:structure
|
transmembrane protein
|
|
gptkbp:UniProtID
|
P19022
|
|
gptkbp:bfsParent
|
gptkb:cadherins
gptkb:PTPRF
gptkb:CDH2
gptkb:cadherin_family
|
|
gptkbp:bfsLayer
|
7
|