Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
LRP-DIT
LRP1B alpha chain LRP1B beta chain Low density lipoprotein receptor-related protein 1B precursor |
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:cancer
|
| gptkbp:discoveredBy |
Herz J et al.
|
| gptkbp:discoveredIn |
2000
|
| gptkbp:encodes |
LRP1B protein
|
| gptkbp:Entrez_Gene_ID |
53353
ENSG00000168702 |
| gptkbp:expressedIn |
gptkb:thyroid
gptkb:cancer gptkb:kidney gptkb:testis brain liver |
| gptkbp:fullName |
Low density lipoprotein receptor-related protein 1B
|
| gptkbp:function |
tumor suppressor
endocytic receptor |
| gptkbp:geneType |
protein-coding
|
| gptkbp:GO_term |
GO:0005886 (plasma membrane)
GO:0005041 (low-density lipoprotein receptor activity) GO:0005515 (protein binding) |
| gptkbp:HGNC_ID |
HGNC:6698
|
| https://www.w3.org/2000/01/rdf-schema#label |
LRP1B
|
| gptkbp:length |
4599 amino acids
91 exons |
| gptkbp:locatedOnChromosome |
chromosome 2
2q22.1 |
| gptkbp:molecularWeight |
~515 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:non-small_cell_lung_cancer
gptkb:cancer gptkb:glioblastoma colorectal cancer melanoma bladder cancer deletion missense mutation hepatocellular carcinoma gastric cancer nonsense mutation frameshift mutation esophageal squamous cell carcinoma |
| gptkbp:OMIM |
608766
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Lrp1b
|
| gptkbp:pathway |
lipid metabolism
cell signaling endocytosis |
| gptkbp:proteinFamily |
gptkb:LDL_receptor_family
|
| gptkbp:UniProtID |
Q9NZR2
|
| gptkbp:bfsParent |
gptkb:low-density_lipoprotein_receptor-related_protein_family
gptkb:gamma-secretase |
| gptkbp:bfsLayer |
8
|