|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
LRP-DIT
LRP1B alpha chain
LRP1B beta chain
Low density lipoprotein receptor-related protein 1B precursor
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:discoveredBy
|
Herz J et al.
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:encodes
|
LRP1B protein
|
|
gptkbp:Entrez_Gene_ID
|
53353
ENSG00000168702
|
|
gptkbp:expressedIn
|
gptkb:thyroid
gptkb:cancer
gptkb:kidney
gptkb:testis
brain
liver
|
|
gptkbp:fullName
|
Low density lipoprotein receptor-related protein 1B
|
|
gptkbp:function
|
gptkb:tumor_suppressor
endocytic receptor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0005886 (plasma membrane)
GO:0005041 (low-density lipoprotein receptor activity)
GO:0005515 (protein binding)
|
|
gptkbp:HGNC_ID
|
HGNC:6698
|
|
gptkbp:length
|
4599 amino acids
91 exons
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
2q22.1
|
|
gptkbp:molecularWeight
|
~515 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:non-small_cell_lung_cancer
gptkb:cancer
gptkb:bladder_cancer
gptkb:glioblastoma
gptkb:melanoma
colorectal cancer
deletion
missense mutation
hepatocellular carcinoma
gastric cancer
nonsense mutation
frameshift mutation
esophageal squamous cell carcinoma
|
|
gptkbp:OMIM
|
608766
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Lrp1b
|
|
gptkbp:pathway
|
lipid metabolism
cell signaling
endocytosis
|
|
gptkbp:proteinFamily
|
gptkb:LDL_receptor_family
|
|
gptkbp:UniProtID
|
Q9NZR2
|
|
gptkbp:bfsParent
|
gptkb:low-density_lipoprotein_receptor-related_protein_family
gptkb:gamma-secretase
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LRP1B
|