Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:neurodegenerative_diseases
|
| gptkbp:clinical_trial |
Alzheimer's disease risk
|
| gptkbp:code |
gptkb:presenilin-2_protein
|
| gptkbp:discovered_by |
researchers in 1996
|
| gptkbp:function |
involved in gamma-secretase complex
|
| gptkbp:genetic_studies |
linked to familial Alzheimer's disease
|
| gptkbp:has_role |
cell signaling
|
| gptkbp:has_variants |
multiple SNPs
|
| https://www.w3.org/2000/01/rdf-schema#label |
PSEN2
|
| gptkbp:interacts_with |
APP
|
| gptkbp:investigates |
clinical trials
pharmacogenomics longitudinal studies |
| gptkbp:involved_in |
notch signaling pathway
|
| gptkbp:is_associated_with |
neuroinflammation
behavioral changes neurodegeneration cognitive resilience memory impairment beta-amyloid production |
| gptkbp:is_essential_for |
neurodevelopment
|
| gptkbp:is_expressed_in |
gptkb:cerebral_cortex
gptkb:Brain gptkb:substantia_nigra glial cells hippocampus peripheral tissues astrocytes |
| gptkbp:is_involved_in |
cell cycle regulation
lipid metabolism neurotransmitter release membrane trafficking calcium signaling cellular signaling pathways synaptic function cellular apoptosis protein processing |
| gptkbp:is_linked_to |
cognitive decline
synaptic plasticity oxidative stress tau pathology age-related cognitive decline vascular contributions to dementia |
| gptkbp:is_part_of |
gptkb:gamma-secretase_complex
genetic counseling neuroprotective strategies neurobiology research neurodegenerative disease research Alzheimer's disease pathology Alzheimer's disease genetics |
| gptkbp:is_regulated_by |
transcription factors
|
| gptkbp:is_related_to |
gptkb:PSEN1_mutations
|
| gptkbp:is_studied_for |
gptkb:gene_therapy
therapeutic efficacy therapeutic targets biomarker development |
| gptkbp:is_studied_in |
genetic research
genetic epidemiology |
| gptkbp:located_in |
human chromosome 1
|
| gptkbp:related_to |
gptkb:PSEN1
|
| gptkbp:targets |
therapeutic interventions
small molecule inhibitors |
| gptkbp:bfsParent |
gptkb:Familial_Alzheimer's_Disease
|
| gptkbp:bfsLayer |
7
|