|
gptkbp:instanceOf
|
transcription factor
|
|
gptkbp:alternativeName
|
gptkb:Proto-oncogene_c-Fos
gptkb:c-Fos
|
|
gptkbp:associatedWith
|
gptkb:cancer
osteosarcoma
cellular stress response
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:degradedBy
|
gptkb:proteasome
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:domain
|
basic leucine zipper (bZIP) domain
|
|
gptkbp:encodedBy
|
gptkb:FOS_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000170345
2353
|
|
gptkbp:expressedIn
|
mammals
|
|
gptkbp:form
|
heterodimers with Jun proteins
|
|
gptkbp:formsComplexWith
|
gptkb:Jun_proteins
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
regulation of differentiation
regulation of transformation
|
|
gptkbp:halfLife
|
short
|
|
gptkbp:HGNC_ID
|
HGNC:3796
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Fos
|
|
gptkbp:involvedIn
|
signal transduction
wound healing
inflammation
immune response
learning and memory
neuronal plasticity
oncogenesis
bone development
|
|
gptkbp:locatedOnChromosome
|
gptkb:human_chromosome_14q24.3
|
|
gptkbp:memberOf
|
AP-1 transcription factor complex
|
|
gptkbp:OMIM
|
164810
|
|
gptkbp:orthologIn
|
gptkb:meat
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:phosphorylates
|
gptkb:MAPK
gptkb:RSK
gptkb:ERK
|
|
gptkbp:product
|
leucine zipper protein
|
|
gptkbp:regulates
|
gene expression
induced by cytokines
induced by growth factors
induced by stress signals
|
|
gptkbp:relatedTo
|
immediate early gene response
|
|
gptkbp:UniProtID
|
P01100
|
|
gptkbp:usedAs
|
marker of neuronal activity
|
|
gptkbp:bfsParent
|
gptkb:Fos_Williams
|
|
gptkbp:bfsLayer
|
7
|