|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activity
|
gptkb:protease
caspase-like
chymotrypsin-like
peptidase
trypsin-like
|
|
gptkbp:alternativeTo
|
gptkb:immunoproteasome
gptkb:spermatoproteasome
gptkb:thymoproteasome
|
|
gptkbp:component
|
ubiquitin-proteasome system
|
|
gptkbp:composedOf
|
gptkb:19S_regulatory_particle
gptkb:20S_core_particle
|
|
gptkbp:degradedBy
|
ubiquitinated proteins
|
|
gptkbp:discoveredBy
|
gptkb:Aaron_Ciechanover
gptkb:Avram_Hershko
gptkb:Irwin_Rose
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
autoimmune diseases
|
|
gptkbp:EC_number
|
3.4.25.1
|
|
gptkbp:foundIn
|
archaea
eukaryotic cells
|
|
gptkbp:function
|
gptkb:ubiquitin-proteasome_pathway
protein degradation
|
|
gptkbp:gene
|
gptkb:PSMA1
gptkb:PSMB1
gptkb:PSMC1
gptkb:PSMD1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
proteasome
|
|
gptkbp:inhibitedBy
|
gptkb:carfilzomib
gptkb:bortezomib
gptkb:lactacystin
|
|
gptkbp:involvedIn
|
immune response
stress response
protein homeostasis
|
|
gptkbp:locatedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
about 2.5 MDa
|
|
gptkbp:NobelPrizeYear
|
gptkb:2004_Nobel_Prize_in_Chemistry
|
|
gptkbp:requires
|
gptkb:ATP
Mg2+
|
|
gptkbp:role
|
apoptosis
cell cycle regulation
protein quality control
antigen processing
|
|
gptkbp:structure
|
barrel-shaped
|
|
gptkbp:subunit
|
regulatory subunit
alpha subunit
beta subunit
|
|
gptkbp:bfsParent
|
gptkb:hypoxia-inducible_factor_1_(HIF-1)
gptkb:beta-catenin
gptkb:Catenin_beta-1
|
|
gptkbp:bfsLayer
|
6
|