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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
cytokines
UV radiation
heat shock
osmotic shock
reactive oxygen species
|
|
gptkbp:alsoKnownAs
|
gptkb:c-Jun_N-terminal_kinases
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodedBy
|
gptkb:MAPK10
gptkb:MAPK9
gptkb:MAPK8
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
regulation of gene expression
apoptosis regulation
cellular stress response
phosphorylation of c-Jun
inflammation regulation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JNK proteins
|
|
gptkbp:involvedIn
|
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:JNK1
|
ubiquitously expressed
|
|
gptkbp:JNK2
|
ubiquitously expressed
|
|
gptkbp:JNK3
|
mainly expressed in brain, heart, and testis
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
|
|
gptkbp:phosphorylates
|
gptkb:Bcl-2
gptkb:tau_protein
gptkb:ATF2
gptkb:Elk-1
gptkb:c-Jun
gptkb:p53
gptkb:STAT3
gptkb:Bim
gptkb:c-Fos
gptkb:Hsp27
gptkb:IRS-1
gptkb:NFAT4
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell migration
transcription factors
cytoskeletal proteins
apoptotic pathways
|
|
gptkbp:subspecies
|
gptkb:JNK1
gptkb:JNK2
gptkb:JNK3
|
|
gptkbp:target
|
pharmacological inhibitors
|
|
gptkbp:bfsParent
|
gptkb:JNK_pathway
|
|
gptkbp:bfsLayer
|
6
|