|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
MAPKK (MAP kinase kinase)
|
|
gptkbp:alternativeName
|
MAP kinase
ERK (for some subtypes)
SAPK (for some subtypes)
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:downstreamOf
|
MAPKKK (MAP kinase kinase kinase)
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:EC_number
|
2.7.11.24
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase
|
|
gptkbp:function
|
signal transduction
phosphorylation of target proteins
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPK
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
cell survival
stress response
|
|
gptkbp:proteinFamily
|
gptkb:MAPK_family
|
|
gptkbp:regulates
|
gene expression
immune response
cell cycle
cytoskeletal rearrangement
|
|
gptkbp:studiedIn
|
biochemistry
cell biology
molecular biology
|
|
gptkbp:subspecies
|
gptkb:JNK
gptkb:p38_MAPK
gptkb:ERK
gptkb:ERK5
|
|
gptkbp:superfamily
|
gptkb:protein_kinase_superfamily
|
|
gptkbp:bfsParent
|
gptkb:MAP_kinase
gptkb:BAD_protein
gptkb:Ras/MAPK_signaling_pathway
gptkb:mitogen-activated_protein_kinase
|
|
gptkbp:bfsLayer
|
6
|