|
gptkbp:instanceOf
|
signaling molecule
|
|
gptkbp:activatedBy
|
stress
growth factors
oxidative stress
hyperosmotic shock
|
|
gptkbp:alsoKnownAs
|
gptkb:Big_MAP_kinase_1_pathway
gptkb:MAPK7_pathway
|
|
gptkbp:database
|
gptkb:KEGG:hsa04016
gptkb:Reactome:R-HSA-198725
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:downstreamOf
|
cell differentiation
cell proliferation
cell survival
angiogenesis
transcriptional regulation
|
|
gptkbp:gene
|
gptkb:MAPK7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ERK5 pathway
|
|
gptkbp:inhibitedBy
|
gptkb:BIX02189
gptkb:XMD8-92
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:cardiovascular_disease
inflammation
|
|
gptkbp:involvesProtein
|
gptkb:ERK5
gptkb:MAPK7
gptkb:MAP2K5
gptkb:MEK5
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:partOf
|
MAPK signaling pathways
|
|
gptkbp:phosphorylates
|
gptkb:MEF2C
gptkb:c-Myc
gptkb:c-Fos
gptkb:MEF2A
gptkb:MEF2D
|
|
gptkbp:regulates
|
gptkb:NF-kB
gptkb:c-Myc
gptkb:c-Fos
gptkb:MEF2_transcription_factors
|
|
gptkbp:relatedTo
|
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
ERK1/2 pathway
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:upstreamActivator
|
gptkb:MAP2K5
gptkb:MEK5
|
|
gptkbp:bfsParent
|
gptkb:MAPK_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|